Evidence map›Paper›PMID 35280098›Full record

ArticleClinical case reports2022

Severe pancytopenia caused by trifluridine/tipiracil in patients with metastatic colorectal cancer and an impaired renal function: A case report.

Masatsune Shibutani, Yuki Okazaki, Shinichiro Kashiwagi, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Masatsune ShibutaniDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.ORCID https://orcid.org/0000-0002-2164-7394
Yuki OkazakiDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Shinichiro KashiwagiDepartment of Breast and Endocrine Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Hisashi NagaharaDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Tatsunari FukuokaDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Yasuhito IsekiDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Kiyoshi MaedaDepartment of Gastroenterological Surgery Osaka City General Hospital Osaka Japan.
Kosei HirakawaDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Masaichi OhiraDepartment of Gastroenterological Surgery Osaka City University Graduate School of Medicine Osaka Japan.
Osaka City University · JPOsaka City General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the incidence of hematological toxicity due to Trifluridine/tipiracil (FTD/TPI) treatment is high, the incidence of severe adverse events has been reported to be relatively low. However, it should be noted that patients with renal impairment are prone to severe hematological adverse events.

Indexed as

colorectal cancerfebrile neutropeniaFTD/TPIneutropeniapancytopenia

Identifiers

PMID35280098
PMCPMC8894575
OpenAlexW4220765307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.