Evidence map›Paper›PMID 35279984›Full record

ArticleRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia2022

Bezlotoxumab in the treatment of Clostridioides difficile infections: a real-life experience.

M Olmedo, M Kestler, M Valerio, B Padilla, C Rodríguez González, E Chamarro, M Machado, A Álvarez-Uría, L Alcalá, P Muñoz and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Real-world use of bezlotoxumab to prevent recurrentTherapeutic advances in gastroenterology · 2025
    Article
  3. Article
  4. The Role of Bezlotoxumab for the Prevention of RecurrentAntibiotics (Basel, Switzerland) · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

M OlmedoMaría Olmedo, Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. maria.olmedo.samperio@gmail.com.
M Kestler
M Valerio
B Padilla
C Rodríguez González
E Chamarro
M Machado
A Álvarez-Uría
L Alcalá
P Muñoz
E Bouza
Hospital General Universitario Gregorio Marañón · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFollowing the approval of bezlotoxumab in 2017, studies evaluating its effectiveness in prevention of Clostridioides difficile infection under "real-life" conditions are scarce.

methodsWe conducted a retrospective study developed in a large tertiary care hospital describing the use and outcomes of patients with Clostridioides difficile infection (CDI) treated with bezlotoxumab.

resultsA total of 16 patients were include, all of whom had an episode of CDI with high probability of recurrence and 14 of them had some kind of immunosuppression. Bezlotoxumab was effective in the prevention of CDI recurrence in 11 of the 14 cases in which follow up was possible, without significant side effects.

conclusionsBezlotoxumab was well tolerated and the incidence of recurrent CDI in a high-risk population for recurrence was only 21.4%.

Indexed as

Clostridioides difficileClostridium InfectionsAnti-Bacterial AgentsAntibodies, MonoclonalBroadly Neutralizing AntibodiesHumansRecurrenceRetrospective StudiesAnti-Bacterial AgentsAntibodies, MonoclonalbezlotoxumabBroadly Neutralizing AntibodiesbezlotoxumabClostridioides difficilerecurrencetreatment

Identifiers

PMID35279984
PMCPMC9134882
OpenAlexW4220969524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.