ArticleTransboundary and emerging diseases2022
Natural disease and evolution of an Amdoparvovirus endemic in striped skunks (Mephitis mephitis).
Article in Transboundary and emerging diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Natural Infection of Domestic Dogs with Raccoon Dog and Fox Amdoparvovirus During a Severe Disease Outbreak.Animals : an open access journal from MDPI · 2026Article
- A novel high-sensitivity TaqMan qPCR assay reveals amdoparvovirus DNA in zoo-housed small mammals in southern China.Veterinary research communications · 2026Article
- Exogenous amdoparvoviruses (Parvoviridae) in arvicoline voles: the molecular evolution and ecology of a novel host-viral association.PLoS pathogens · 2026Article
- A Novel Amdoparvovirus of Badgers and Foxes and the Perpetuation of Aleutian Mink Disease Virus 3 in the Wildlife of Denmark.Pathogens (Basel, Switzerland) · 2025Article
- Prevalence of Aleutian Mink Disease Virus (AMDV) in Free-Ranging American Mink from Biebrza and Narew National Parks (Poland)-An Epidemiological Concern.Animals : an open access journal from MDPI · 2024Article
- Diverse amdoparvoviruses infection of farmed Asian badgers (Meles meles).Archives of virology · 2024Article
- A developed TaqMan probe-based qPCR was used to quantify the distribution of AMDV in various tissues of infected mink and its prevalence in northern China.Frontiers in veterinary science · 2024Article
- Amdoparvovirus-associated disease in striped skunks (Veterinary pathology · 2023Article
- First Report of Skunk Amdoparvovirus (SpeciesViruses · 2023Article
- Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates.PLoS biology · 2022Article
- A new perspective on the evolution and diversity of the genusVirus evolution · 2022Article
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
Striped skunks (Mephitis mephitis) densely populate the human-animal interface of suburbia throughout North America. Skunks share that habitat with numerous related mesocarnivores, where increased contact, competition for shared food and water sources and other stressors contribute to increased exposure and susceptibility to viral infection. The recently identified skunk amdoparvovirus (SKAV) has been detected at high prevalence in skunks and occasionally in mink, but its distribution in North America is unknown. To understand the impact of SKAV in striped skunks and the risk posed to related species, we investigated the geographic distribution of SKAV, analysed its genetic diversity and evolutionary dynamics and evaluated viral distribution in tissues of infected animals to identify possible mechanisms of transmission. SKAV was detected in 72.5% (37/51) skunks and was present at high rates at all locations tested across North America. Analysis of the complete genomic sequence of 29 strains showed a clear geographic segregation, frequent recombination and marked differences in the evolutionary dynamics of the major structural (VP2) and non-structural (NS1) proteins. NS1 was characterized by a higher variability and a higher percentage of positively selected codons. This could indicate that antibody-mediated enhancement of infection occurs in SKAV, an infection strategy that may be conserved across amdoparvoviruses. Finally, in situ hybridization revealed virus in epithelium of the gastrointestinal tract, urinary tract and skin, indicating that viral transmission could occur via oronasal, faecal and/or urinary secretions, as well as from skin and hair. The endemicity of SKAV over large geographic distances and its high genetic diversity suggest a long-term virus-host association. Persistent shedding and high environmental stability likely contribute to efficient viral spread, simultaneously offering opportunities for cross-species transmission with consequent risk to sympatric species, including domestic animals and wildlife.
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