Evidence map›Paper›PMID 35279798›Full record

ArticleRheumatology and therapy2022

Experiences and Treatment Preferences in Patients With Psoriatic Arthritis: A Cross-Sectional Study in the ArthritisPower Registry.

Alexis Ogdie, Kelley Myers, Carol Mansfield, William Tillett, Peter Nash, Colton Leach, W Benjamin Nowell, Kelly Gavigan, Patrick Zueger, Erin McDearmon-Blondell and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Rheumatology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Alexis OgdieDivision of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kelley MyersRTI Health Solutions, 3040 East Cornwallis Road, Post Office Box 12194, Research Triangle Park, NC, 27709-2194, USA. kmyers@rti.org.ORCID http://orcid.org/0000-0002-0936-5677
Carol MansfieldRTI Health Solutions, 3040 East Cornwallis Road, Post Office Box 12194, Research Triangle Park, NC, 27709-2194, USA.
William TillettDepartment of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, UK.
Peter NashDepartment of Medicine, Griffith University, Brisbane, QLD, Australia.
Colton LeachRTI Health Solutions, 3040 East Cornwallis Road, Post Office Box 12194, Research Triangle Park, NC, 27709-2194, USA.
W Benjamin NowellGlobal Healthy Living Foundation, Upper Nyack, NY, USA.
Kelly GaviganGlobal Healthy Living Foundation, Upper Nyack, NY, USA.
Patrick ZuegerAbbVie Inc., North Chicago, IL, USA.
Erin McDearmon-BlondellAbbVie Inc., North Chicago, IL, USA.
Jessica WalshDivision of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
RTI Health Solutions · USAbbVie (United States) · USGlobal Healthy Living Foundation · USGriffith University · AURoyal National Hospital for Rheumatic Diseases · GBUniversity of Pennsylvania · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite recent advances in treatment for psoriatic arthritis (PsA), many patients experience inadequate response or intolerance to therapy, indicating that unmet treatment-related needs remain. To further characterize these unmet needs, we evaluated patients' experiences regarding the burden of PsA symptoms and disease impacts, and patients' preferences for treatment.

methodsPatients from ArthritisPower, a rheumatology research registry, completed a web-based survey. Object case best-worst scaling (BWS) was used to evaluate the relative burden of 11 PsA-related symptoms and the relative importance of improvement in nine PsA-related disease impacts. BWS data were analyzed using a random-parameters logit model. Patient demographics, preferences for mode and frequency of therapy, and preferences for methotrexate were analyzed descriptively.

resultsAmong the 332 participants, most were White (94%), female (80%), with mean age of 54 years (SD 11.4). In the BWS, joint pain was the most bothersome symptom, followed by other musculoskeletal pain and fatigue. The BWS for disease impacts found that improvements in the ability to perform physical activities were most important, followed by improvements in the ability to function independently, sleep quality, and the ability to perform daily activities. The most burdensome symptoms and desired disease impact improvements were similar in patients regardless of their experience with biologic disease-modifying antirheumatic drugs. The most preferred mode and frequency of treatment administration was oral, once-daily medication (preferred by 38% of respondents), and 74% prioritized therapies that significantly improved joint-related symptoms versus psoriasis-related symptoms. The majority of respondents (65%) preferred PsA treatment regimens that did not include methotrexate.

conclusionsPatients with PsA from a rheumatology registry found musculoskeletal pain symptoms to be the most bothersome and prioritized improvements to functional impacts of their disease. These findings can better inform development of new therapies and guide shared patient-provider treatment decision-making.

Indexed as

Best–worst scalingDisease impactsJoint painPatient preferencesPsoriatic arthritis

Identifiers

PMID35279798
PMCPMC8964868
OpenAlexW4220925623

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.