Evidence map›Paper›PMID 35279757›Full record

ArticleJournal of neurology2022

Schizotypal traits across the amyotrophic lateral sclerosis-frontotemporal dementia spectrum: pathomechanistic insights.

Nga Yan Tse, Sicong Tu, Yu Chen, Jashelle Caga, Carol Dobson-Stone, John B Kwok, Glenda M Halliday, Rebekah M Ahmed, John R Hodges, Olivier Piguet and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Psychiatric disorders in amyotrophic lateral sclerosis: a short note.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Nga Yan TseThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Sicong TuThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Yu ChenSchool of Psychology and Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Jashelle CagaThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Carol Dobson-StoneThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
John B KwokThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Glenda M HallidayThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Rebekah M AhmedThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
John R HodgesThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Olivier PiguetSchool of Psychology and Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Matthew C KiernanThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia.
Emma M DevenneyThe Brain and Mind Centre, University of Sydney; and Royal Prince Alfred Hospital, 94 Mallet Street, Camperdown, Sydney, NSW, 2050, Australia. Emma.devenney@sydney.edu.au.ORCID http://orcid.org/0000-0001-6140-0452
The University of Sydney · AU

Funding

Centre of Excellence in Cognition and its Disorders, Australian Research Council CE110001021National Health and Medical Research Council 1037746National Health and Medical Research Council 1095127National Health and Medical Research Council 1132524National Health and Medical Research Council 1176607National Health and Medical Research Council APP1103258National Health and Medical Research Council APP1121859National Health and Medical Research Council Post-doctoral fellowship
6 · The paper itself

Abstract

backgroundPsychiatric presentations similar to that observed in primary psychiatric disorders are well described across the amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum. Despite this, schizotypal personality traits associated with increased risks of clinical psychosis development and poor psychosocial outcomes have never been examined. The current study aimed to provide the first exploration of schizotypal traits and its neural underpinnings in the ALS-FTD spectrum to gain insights into a broader spectrum of psychiatric overlap with psychiatric disorders.

methodsSchizotypal traits were assessed using the targeted Schizotypal Personality Questionnaire in 99 participants (35 behavioural variant FTD, 10 ALS-FTD and 37 ALS patients, and 17 age-, sex- and education-matched healthy controls). Voxel-based morphometry analysis of whole-brain grey matter volume was conducted.

resultsRelative to controls, pervasive schizotypal personality traits across positive and negative schizotypy and disorganised thought disorders were identified in behavioural variant FTD, ALS (with the exception of negative schizotypy) and ALS-FTDALS-FTD patients (all p < .013), suggesting the presence of a wide spectrum of subclinical schizotypal symptoms beyond classic psychotic symptoms. Atrophy in frontal, anterior cingulate and insular cortices, and caudate and thalamus was involved in positive schizotypy, while integrity of the cerebellum was associated with disorganised thought disorder traits.

conclusionsThe frontal-striatal-limbic regions underpinning manifestation of schizotypy in the ALS-FTDALS-FTD spectrum are similar to that established in previous schizophrenia research. This finding expands the concept of a psychiatric overlap in ALS-FTD and schizophrenia, and suggests potentially common underlying mechanisms involving disruptions to frontal-striatal-limbic networks, warranting a transdiagnostic approach for future investigations.

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaAtrophyGray MatterHumansAmyotrophic lateral sclerosisFrontotemporal dementiaMotor neuron diseaseNeuropsychiatrySchizotypy

Identifiers

PMID35279757
PMCPMC9294025
OpenAlexW4221107747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.