Evidence map›Paper›PMID 35279756›Full record

ArticleJournal of neurology2022

Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study.

Maria-Eleni Dounavi, Coco Newton, Natalie Jenkins, Elijah Mak, Audrey Low, Graciela Muniz-Terrera, Guy B Williams, Brian Lawlor, Lorina Naci, Paresh Malhotra and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  4. Beyond binary classification: Comparing three region-based multi-phase Aβ staging systems.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  10. Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  11. Review
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  17. Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  18. Controlling the Impact ofMedicina (Kaunas, Lithuania) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Maria-Eleni DounaviDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Coco NewtonDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Natalie JenkinsCentre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
Elijah MakDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Audrey LowDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Graciela Muniz-TerreraCentre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
Guy B WilliamsDepartment of Clinical Neurosciences and Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Brian LawlorInstitute of Neuroscience, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Lorina NaciInstitute of Neuroscience, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Paresh MalhotraDivision of Brain Science, Imperial College Healthcare NHS Trust, London, UK.
Clare E MackayDepartment of Psychiatry, Oxford University, Oxford, UK.
Ivan KoychevDepartment of Psychiatry, Oxford University, Oxford, UK.
Karen RitchieCentre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
Craig W RitchieCentre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
Li SuDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
John T O'BrienDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK. john.obrien@medschl.cam.ac.uk.
University of Cambridge · GBUniversity of Edinburgh · GBTrinity College Dublin · IEUniversity of Oxford · GBImperial College Healthcare NHS Trust · GBInserm · FRUniversity of Sheffield · GB

Funding

Alzheimer's Association TriBEKa-17-519007Alzheimer's Society 264Alzheimer's Society 397Medical Research Council MR/M024962/1
6 · The paper itself

Abstract

backgroundMacrostructural brain alterations in the form of brain atrophy or cortical thinning typically occur during the prodromal Alzheimer's disease stage. Mixed findings largely dependent on the age of the examined cohorts have been reported during the preclinical, asymptomatic disease stage. In the present study, our aim was to examine the association of midlife dementia risk with brain macrostructural alterations.

methodsStructural 3T MRI scans were acquired for 647 cognitively normal middle-aged (40-59 years old) participants in the PREVENT-Dementia study. Cortical thickness, volumes of subcortical structures, the hippocampus and hippocampal subfields were quantified using Freesurfer version 7.1. The clarity of the hippocampal molecular layer was evaluated based on T2-weighted hippocampal scans. Associations of structural measures with apolipoprotein ε4 (APOE4) genotype and dementia family history (FHD), were investigated using linear regression. Correlations between the CAIDE dementia risk score (incorporating information about blood pressure, cholesterol, physical activity, body mass index, education, age and sex) and structural measures were further investigated.

resultsA higher CAIDE score was associated with thinner cortex and a larger hippocampal fissure. APOE4 genotype was associated with reduced molecular layer clarity.

conclusionsOur findings suggest that a higher CAIDE score is associated with widespread cortical thinning. Conversely, APOE4 carriers and participants with FHD do not demonstrate prominent macrostructural alterations at this age range. These findings indicate that cardiovascular and not inherited risk factors for dementia are associated with macrostructural brain alterations at midlife.

Indexed as

Alzheimer DiseaseApolipoprotein E4AdultAtrophyBrainCerebral Cortical ThinningHumansMagnetic Resonance ImagingMiddle AgedApolipoprotein E4Alzheimer’s diseaseAPOECortical thicknessDementia riskHippocampal subfields

Identifiers

PMID35279756
PMCPMC9294019
OpenAlexW4221019783

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.