ArticleBrain structure & function2022
Dual medial prefrontal cortex and hippocampus projecting neurons in the paraventricular nucleus of the thalamus.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- PVT inhibition mitigates neuropathology and cognitive deficits in chronic cerebral hypoperfusion.iScience · 2026Article
- A GABAergic pathway from dorsal raphe nucleus to paraventricular thalamic nucleus modulates incision-related pain behaviour in mice.Brain communications · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Chemogenetic Inhibition and Optogenetic Depotentiation of the Prelimbic Cortex to Paraventricular Thalamus Pathway Attenuate Abstinence-Induced Plasticity and Heroin Seeking in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting.Neuroscience bulletin · 2025Article
- Lateralization of Hippocampal Dentate Spikes and Sharp-Wave Ripples in Urethane Anesthetized Rats Depends on Cholinergic Tone.Hippocampus · 2025Article
- Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior.Communications biology · 2025Article
- Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.Psychopharmacology · 2025Article
- Article
- The Paraventricular Thalamic Nucleus and Its Projections in Regulating Reward and Context Associations.eNeuro · 2024Article
- Sex differences in cognition following variations in endocrine status.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Review
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Authors and funding
3 authors.
Funding
Abstract
The paraventricular nucleus (PVT) of the midline thalamus is a critical higher-order cortico-thalamo-cortical integration site that plays a critical role in various behaviors including reward seeking, cue saliency, and emotional memory. Anatomical studies have shown that PVT projects to both medial prefrontal cortex (mPFC) and hippocampus (HC). However, dual mPFC-HC projecting neurons which could serve a role in synchronizing mPFC and HC activity during PVT-dependent behaviors, have not been explored. Here we used a dual retrograde adenoassociated virus (AAV) tracing approach to characterize the location and proportion of different projection populations that send collaterals to mPFC and/or ventral hippocampus (vHC) in rats. Additionally, we examined the distribution of calcium binding proteins calretinin (CR) and calbindin (CB) with respect to these projection populations in PVT. We found that PVT contains separate populations of cells that project to mPFC, vHC, and those that innervate both regions. Interestingly, dual mPFC-HC projecting cells expressed neither CR nor CB. Topographically, CB
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