Evidence map›Paper›PMID 35279696›Full record

ArticleScientific reports2022

Structure and activity of the DHNA Coenzyme-A Thioesterase from Staphylococcus aureus providing insights for innovative drug development.

Aline Melro Murad, Hévila Brognaro, Sven Falke, Jasmin Lindner, Markus Perbandt, Celestin Mudogo, Robin Schubert, Carsten Wrenger, Christian Betzel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. In Situ Online Spectroscopy and Light Scattering Techniques.Advances in biochemical engineering/biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aline Melro MuradInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany.
Hévila BrognaroInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany.
Sven FalkeInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany.
Jasmin LindnerUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1374, São Paulo, SP, 05508-000, Brazil.
Markus PerbandtInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany.
Celestin MudogoInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany.
Robin SchubertInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany.
Carsten WrengerUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1374, São Paulo, SP, 05508-000, Brazil.
Christian BetzelInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University Hamburg, c/o DESY, Build. 22A, Notkestraße 85, 22603, Hamburg, Germany. christian.betzel@uni-hamburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humanity is facing an increasing health threat caused by a variety of multidrug resistant bacteria. Within this scenario, Staphylococcus aureus, in particular methicillin resistant S. aureus (MRSA), is responsible for a number of hospital-acquired bacterial infections. The emergence of microbial antibiotic resistance urgently requires the identification of new and innovative strategies to treat antibiotic resistant microorganisms. In this context, structure and function analysis of potential drug targets in metabolic pathways vital for bacteria endurance, such as the vitamin K

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsCoenzyme ADrug DevelopmentHumansMicrobial Sensitivity TestsStaphylococcus aureusVitamin KAnti-Bacterial AgentsCoenzyme AVitamin K

Identifiers

PMID35279696
PMCPMC8918352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.