ArticleBiological psychiatry2022
Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.
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Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
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- Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors.Biology of sex differences · 2026Article
- Beyond traditional sleeping pills: safety, efficacy and multidisease potential of three approved orexin receptor antagonists.Frontiers in psychiatry · 2026Review
- A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis.Science advances · 2025Article
- Acute carbamoylated erythropoietin reduces social stress-induced anxiety and depression-related behaviors.Neuropharmacology · 2025Article
- The Orexin System in Addiction: Neuromodulatory Interactions and Therapeutic Potential.Brain sciences · 2025Review
- Aggression as a contributing factor to social defeat and stress vulnerability.Neurobiology of stress · 2025Article
- Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear.Psychopharmacology · 2025Article
- Hypocretin: a promising target for the regulation of homeostasis.Frontiers in neuroscience · 2025Review
- Learned phenotypes emerge during social stress modifying hippocampal orexin receptor gene expression.Scientific reports · 2024Article
- Hypocretin in the nucleus accumbens shell modulates social approach in female but not male California mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation.British journal of pharmacology · 2024Review
- Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress.Neuropharmacology · 2024Article
- Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024Review
- The role of the orexin system in the neurobiology of anxiety disorders: Potential for a novel treatment target.Neuroscience applied · 2024Review
- Resilience and its correlates in patients with narcolepsy type 1.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder.Neuropharmacology · 2023Review
- Anxiolytic reversal of classically conditioned / chronic stress-induced gene expression and learning in the Stress Alternatives Model.Behavioural brain research · 2023Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Jazmine D W YaegerDepartment of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, South Dakota.
Kevin T KruppDepartment of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota.
Benjamin M JacobsDepartment of Biology, University of South Dakota, Vermillion, South Dakota; Texas Christian University School of Medicine, Fort Worth, Texas.
Benard O OnserioDepartment of Biology, University of South Dakota, Vermillion, South Dakota.
Brandon L MeyerinkNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, South Dakota.
Jacob T CainPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, South Dakota.
Patrick J RonanNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, South Dakota.
Kenneth J RennerDepartment of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota.
Ralph J DiLeoneDivision of Molecular Psychiatry, Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Cliff H SummersDepartment of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, South Dakota. Electronic address: cliff@usd.edu.
University of South Dakota · USSanford Research · USTexas Christian University · USYale University · US
Funding
Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI SCHWARTZ, GARY G · 2018 to 2022
$20.3MSPURA - Summer Program for Undergraduate Research in AddictionR25DA033674 · NIDA · UNIVERSITY OF SOUTH DAKOTA · PI Bridget Diamond-Welch, Yohaan M. Fernandes · 2013 to 2026
$1.0MSex Differences in the Neurobiological Significance of Orexin Stress SignalingR15MH125306 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2021 to 2021
$427kAmygdalar Orexin Modulation of Affective DisordersR15MH104485 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2015 to 2015
$426kNIDA NIH HHS R25 DA033674NIGMS NIH HHS U54 GM128729NIMH NIH HHS R15 MH104485NIMH NIH HHS R15 MH125306
Abstract
backgroundStress produces differential behavioral responses through select molecular modifications to specific neurocircuitry elements. The orexin (Orx) system targets key components of this neurocircuitry in the basolateral amygdala (BLA).
methodsWe assessed the contribution of intra-BLA Orx
resultsIn the BLA, we observed that Orx
conclusionsFunctional reorganization of intra-BLA gene expression is produced by antagonism of Orx
Indexed as
Basolateral Nuclear ComplexOrexin ReceptorsAnimalsAnxietyBrain-Derived Neurotrophic FactorMiceRNA, MessengerSignal TransductionBrain-Derived Neurotrophic FactorHcrtr1 protein, mouseOrexin ReceptorsRNA, MessengerAnxious behaviorFear conditioningHypocretinResilienceSocial stressStress Alternatives Model
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.