SynthesisJournal of orthopaedic surgery and research2022
Risk factors of vertebral re-fracture after PVP or PKP for osteoporotic vertebral compression fractures, especially in Eastern Asia: a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
110 citing papers in PubMed, 8 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Prediction models for subsequent vertebral fractures after percutaneous vertebroplasty or kyphoplasty: a systematic review and critical appraisal.BMC musculoskeletal disorders · 2026Pooled it
- Risk factors for new vertebral compression fracture following percutaneous vertebral augmentation: a systematic review and meta-analysis based on multivariate logistic regression analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Risk factors for adjacent vertebral fracture after kyphoplasty or percutaneous vertebroplasty in osteoporotic vertebral systematic review and meta-analysis compression fractures.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- Risk factors for new vertebral fracture after percutaneous vertebroplasty or kyphoplasty for osteoporotic vertebral compression fractures (OVCFs): an updated systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- The Prevalence and Risk Factors of Residual Back Pain After Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis.Orthopaedic surgery · 2025Pooled it
- Risk factors for refracture or new vertebral compression fractures after percutaneous vertebroplasty: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Prediction models for adjacent vertebral fractures after vertebral augmentation: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- The Relation of Osteoporotic Vertebral Fractures and Sarcopenic Characteristics on the Occurrence of Complications: A Systematic Review.Clinical interventions in aging · 2025Pooled it
- Comparative efficacy of percutaneous vertebroplasty combined with minimally invasive pedicle screw fixation versus percutaneous vertebroplasty alone in the treatment of elderly osteoporotic vertebral compression fractures.The Libyan journal of medicine · 2026Trial
- Paraspinal muscle CT measurements in predicting subsequent fractures after percutaneous kyphoplasty in elderly women.North American Spine Society journal · 2026Article
- CALLY index and bone mineral density as risk factors for adjacent vertebral fracture after balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: a retrospective analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Incidence and Independent Risk Factors of Spinal Infection After Vertebral Augmentation: A Multicenter Propensity-Matched Case-Control Study.Neurospine · 2026Article
- Combine Short-Segment Fixation and Leverage Reduction Technique to Correct Kyphotic Angle in Kümmell's Disease.Orthopaedic surgery · 2026Article
- Osteoporosis: The Renascent Impact of Vertebral Fractures-A Narrative Review of Diagnosis, Risk Stratification, and Integrated Management.Journal of clinical medicine · 2026Review
- Prediction of refracture risk after osteoporotic vertebral compression fracture surgery using the vertebral bone quality index from multi-sequence MRI.Scientific reports · 2026Article
- Percutaneous vertebroplasty and percutaneous kyphoplasty for osteoporotic vertebral compression fractures: medium- and long-term evaluation of clinical outcomes and affecting factors.BMC musculoskeletal disorders · 2026Article
- Development and validation of a nomogram model for predicting bone cement leakage during vertebroplasty.BMC surgery · 2026Article
- Article
- Manual reduction combined with percutaneous vertebroplasty versus percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures.Joint diseases and related surgery · 2026Article
- Association between baseline lipid levels and re-fracture after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePercutaneous vertebroplasty (PVP) and kyphoplasty (PKP) have been widely used to treat osteoporotic vertebral compression fractures (OVCF), but the risk of vertebral re-fracture after PVP/PKP remains controversial. This study aims to investigate the incidence and risk factors of vertebral re-fracture after PVP/PKP.
methodsRelevant literatures published up to November 2021 were collected from PubMed, Embase and Web of Science. A meta-analysis was performed to extract data associated with risk factors of SVCF following the PRISMA guidelines. Also, pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI) was calculated.
resultsA total of 23 studies, encompassing 9372 patients with OVCF, met the inclusion criteria. 1255 patients (13.39%) suffered re-fracture after PVP/PKP surgery. A total of 22 studies were from Eastern Asia and only 1 study was from Europe. Female sex (OR = 1.34, 95%CI 1.09-1.64, P = 0.006), older age (WMD = 2.04, 95%CI 0.84-3.24, P = 0.001), lower bone mineral density (BMD, WMD = - 0.38, 95%CI - 0.49-0.26, P < 0.001) and bone cement leakages (OR = 2.05, 95% CI 1.40-3.00, P < 0.001) increased the risk of SVCF. The results of subgroup analysis showed the occurrence of re-fracture was significantly associated with gender (P = 0.002), age (P = 0.001) and BMD (P < 0.001) in Eastern Asia. Compared with the unfractured group, anterior-to-posterior vertebral body height ratio (AP ratio, WMD = 0.06, 95%CI 0.00-0.12, P = 0.037) and visual analog scale score (VAS, WMD = 0.62, 95%CI 0.09-1.15, P = 0.022) were higher in the refracture group, and kyphotic angle correction ratio (Cobb ratio, WMD = - 0.72, 95%CI - 1.26-0.18, P = 0.008) was smaller in Eastern Asia. In addition, anti-osteoporosis treatment (OR = 0.40, 95% CI 0.27-0.60, P < 0.001) could be a protective factor.
conclusionThe main factors associated with re-fracture after PVP/PKP are sex, age, bone mineral density, AP ratio, Cobb ratio, VAS score, bone cement leakage and anti-osteoporosis treatment, especially in Eastern Asia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.