ArticleBMC infectious diseases2022
Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection: retrospective cohort study.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 16 citations in OpenAlex.
- Association of obesity and nutritional status on early sepsis-associated acute kidney injury in older patients with sepsis.BMC nephrology · 2026Article
- Sepsis in Frail Older Adults: Tailored Antimicrobial Stewardship and Individualized Care Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Non-linear association between lactate and 28 days mortality in elderly patients with sepsis across different SOFA score groups: results from the eICU Collaborative Research Database.Frontiers in medicine · 2025Article
- Predicting microRNAs and their Target Genes Involved in Sepsis Pathogenesis by using Bioinformatics Methods.Current pharmaceutical design · 2025Article
- Risk Factors and Mortality Outcomes in Elderly Patients With Bloodstream Infections: A Retrospective Analysis.Cureus · 2024Article
- Nomogram predictive model for in-hospital mortality risk in elderly ICU patients with urosepsis.BMC infectious diseases · 2024Article
- Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens.Frontiers in cellular and infection microbiology · 2024Article
- Impact of beta-blocker usage on delirium in patients with sepsis in ICU: a cross-sectional study.Frontiers in medicine · 2024Article
- Association between delayed invasive blood pressure monitoring and all-cause mortality in intensive care unit patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2024Article
- Risk Factors for Bacteremia and Its Clinical Impact on Complicated Community-Acquired Urinary Tract Infection.Microorganisms · 2023Article
- Association Between Lactate and 28-Day Mortality in Elderly Patients with Sepsis: Results from MIMIC-IV Database.Infectious diseases and therapy · 2023Article
- Patient predictors of pathogenic versus commensal Gram-positive bacilli organisms isolated from blood cultures.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Association between geriatric nutritional risk index and 28 days mortality in elderly patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2023Article
- Influence of early enteral nutrition plus probiotics on intestinal function of senile patients with sepsis.American journal of translational research · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn older adult patients, bloodstream infections cause significant mortality. However, data on long-term prognosis in very elderly patients are scarce. This study aims to assess 1-year mortality from bacteraemia in very elderly patients.
methodsRetrospective cohort study in inpatients aged 80 years or older and suspected of having sepsis. Patients with (n = 336) and without (n = 336) confirmed bacteraemia were matched for age, sex, and date of culture, and their characteristics were compared. All-cause mortality and risk of death were assessed using the adjusted hazard ratio (aHR).
resultsCompared to controls, cases showed a higher 1-year mortality (34.8% vs. 45.2%) and mortality rate (0.46 vs. 0.69 deaths per person-year). Multivariable analysis showed significant risk of 1-year mortality in patients with bacteraemia (aHR: 1.31, 95% confidence interval [CI] 1.03-1.67), quick Sepsis Related Organ Failure Assessment (qSOFA) score of 2 or more (aHR: 2.71, 95% CI 2.05-3.57), and age of 90 years or older (aHR 1.53, 95% CI 1.17-1.99).
conclusionsIn elderly patients suspected of sepsis, bacteraemia is associated with a poor prognosis and higher long-term mortality. Other factors related to excess mortality were age over 90 years and a qSOFA score of 2 or more.
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