ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2022
C-Reactive Protein, Subjective Aging, and Incident Cardiovascular Disease: A Mediation Model.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cumulative inflammatory index and the risk of cardiometabolic multimorbidity: a prospective cohort study among middle-aged and older adults in China.Journal of health, population, and nutrition · 2026Article
- Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults.Nature communications · 2025Article
- Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999-2002.Clinical epigenetics · 2025Article
- Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function.International journal of medical sciences · 2025Article
- Association of C-reactive protein to albumin ratio with all-cause and cardiovascular mortality in patients with chronic kidney disease stages 3-5.Environmental health and preventive medicine · 2025Article
- Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study.Frontiers in nutrition · 2025Article
- Changes in sarcopenia and incident cardiovascular disease in prospective cohorts.BMC medicine · 2024Article
- The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms.Frontiers in pharmacology · 2024Review
- Combined impact of elevated C-reactive protein levels and dyslipidemia on stroke: a CHNS prospective cohort study.Frontiers in public health · 2024Article
- Early-stage non-alcoholic fatty liver disease in relation to atherosclerosis and inflammation.Clinics (Sao Paulo, Brazil) · 2023Article
- Correlates of felt age in caregivers of people with dementia: findings from the IDEAL study.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectivesNegative self-perceptions of aging (SPA) and an older subjective age are associated with a greater likelihood of cardiovascular disease. We predicted that C-reactive protein (CRP), a marker of stress-related inflammation, would mediate this relation.
methodData from up to 6 602 participants ages 50-101 in the Health and Retirement Study (2008-2018) were analyzed using logistic regressions with mediation. Subjective aging was assessed in 2008 or 2010, CRP was assessed 2 years later, and diagnosis of heart disease or stroke was assessed in the years from CRP measurement to 2018.
resultsSignificant indirect effects occurred in all models, indicating that negative SPA and older subjective age are associated with a greater likelihood of heart disease and stroke through elevated levels of the inflammatory marker CRP. DISCUSSION: These findings suggest that psychological factors such as subjective aging impact cardiovascular health through physiological mechanisms, specifically markers of inflammation.
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