ArticleClinical imaging2022
Incidence, clinical associations and outcomes of intrathoracic complications with and without ARDS in COVID-19 pneumonia.
Article in Clinical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Predictors of ICU Length of Stay in Patients with Severe Pneumonia: A Six-Year Retrospective Cohort Study Focusing on Traditional Chinese Medicine Adjuvant Therapy.International journal of general medicine · 2026Article
- Evolution of SARS-CoV-2 related pneumatoceles: A case report.Respiratory medicine case reports · 2024Article
- Pleural Effusion in COVID-19 Pneumonia: Clinical and Prognostic Implications-An Observational, Retrospective Study.Journal of clinical medicine · 2023Article
- Macklin effect on baseline chest CT scan accurately predicts barotrauma in COVID-19 patients.Respiratory medicine · 2022Observational
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine the incidence and clinical predictors of intrathoracic complications in COVID-19 patients, and the association with outcomes.
methodsIn this retrospective cross-sectional study, we included 976 patients (age 61 ± 17 years, 62% male) who tested positive for SARS-CoV-2 between March 3-April 4, 2020 and underwent chest imaging. 3836 radiographs from 976 patients and 105 CTs from 88 patients were reviewed for intrathoracic complications, including pneumothorax, pneumomediastinum, pneumopericardium, lobar collapse, pleural effusion, and pneumatocele formation.
resultsThere was a high rate of intrathoracic complications (197/976, 20%). Pleural effusion was the most common complication (168/976, 17%). Pneumothorax (30/976, 3%) and pneumatoceles (9/88, 10%) were also frequent. History of hypertension and high initial CXR severity score were independent risk factors for complications. Patients with any intrathoracic complication during admission had an over 11-fold risk of ICU admission (adjusted odds ratio [aOR] 11.2, p < 0.0001) and intubation (aOR 12.4, p < 0.0001), over 50% reduction in successful extubation (aOR 0.49, p = 0.02) and longer length of stay (median 13 versus 5 days, p < 0.0001). There was no difference in overall survival between patients with and without any complication (log-rank p = 0.94).
conclusionIn COVID-19 patients who underwent chest imaging, 1 in 5 patients have an intrathoracic complication, which are associated with higher level of care and prolonged hospital stay. Hypertension history and high CXR severity score confer an increased risk of complication. SUMMARY: Intrathoracic complications in COVID-19 are common and are predictive of ICU admission, need for intubation, less successful extubation, and longer length of stay but are not predictive of mortality.
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