Evidence map›Paper›PMID 35278714›Full record

ArticleGenomics, proteomics & bioinformatics2023

LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.

Oh Kwang Kwon, In Hyuk Bang, So Young Choi, Ju Mi Jeon, Ann-Yae Na, Yan Gao, Sam Seok Cho, Sung Hwan Ki, Youngshik Choe, Jun Nyung Lee and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, proteomics & bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Oh Kwang KwonBK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
In Hyuk BangDepartment of Biochemistry and Molecular Biology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea.
So Young ChoiBK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Ju Mi JeonBK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Ann-Yae NaBK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Yan GaoBK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Sam Seok ChoCollege of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
Sung Hwan KiCollege of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
Youngshik ChoeKorea Brain Research Institute, Daegu 41068, Republic of Korea.
Jun Nyung LeeDepartment of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Urology, Kyungpook National University Hospital, Daegu 41566, Republic of Korea.
Yun-Sok HaDepartment of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Urology, Kyungpook National University Hospital, Daegu 41566, Republic of Korea.
Eun Ju BaeCollege of Pharmacy, Chonbuk University, Jeonju, Jeonbuk 54896, Republic of Korea.
Tae Gyun KwonDepartment of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Urology, Kyungpook National University Hospital, Daegu 41566, Republic of Korea. Electronic address: tgkwon@knu.ac.kr.
Byung-Hyun ParkDepartment of Biochemistry and Molecular Biology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea. Electronic address: bhpark@jbnu.ac.kr.
Sangkyu LeeBK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: sangkyu@knu.ac.kr.
Kyungpook National University · KRJeonbuk National University · KRKyungpook National University Hospital · KRChosun University · KRKorea Brain Research Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Around 80% of the patients who developed advanced PCa suffered from bone metastasis, with a sharp drop in the survival rate. Despite great efforts, the detailed mechanisms underlying castration-resistant PCa (CRPC) remain unclear. Sirtuin 5 (SIRT5), an NAD

Indexed as

Prostatic NeoplasmsSirtuinsHumansLactate Dehydrogenase 5MaleLactate Dehydrogenase 5SIRT5 protein, humanSirtuinsLactate dehydrogenase ALysine succinylationPCa progressionSirtuin 5

Identifiers

PMID35278714
PMCPMC10372916
OpenAlexW4220859501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.