Evidence map›Paper›PMID 35278693›Full record

ArticleContemporary clinical trials2022

A customized adherence enhancement program for adolescents and young adults with suboptimal adherence and bipolar disorder: Trial design and methodological report.

Molly McVoy, Melissa Delbello, Jennifer Levin, Avani C Modi, Larry F Forthun, Farren Briggs, Deionte Appling, Michaela Broadnax, Carla Conroy, Raechel Cooley and 2 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07628647 (Pilot Study of the Living Well With Brain Cancer Intervention), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07628647 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Study of the Living Well With Brain Cancer Intervention

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2027Enrolled64ConditionsBrain CancerArmsGroup Self-Management Sessions, Educational Materials Only
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Molly McVoyDepartment of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Case Western Reserve University School of Medicine, Cleveland, OH, United States of America; Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America. Electronic address: Molly.McVoy@uhhospitals.org.
Melissa DelbelloUniversity of Cincinnati, College of Medicine, Cincinnati, OH, United States of America.
Jennifer LevinDepartment of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Case Western Reserve University School of Medicine, Cleveland, OH, United States of America; Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America.
Avani C ModiDivision of Behavioral Medicine and Clinical Psychology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America; University of Cincinnati, College of Medicine, Cincinnati, OH, United States of America.
Larry F ForthunDepartment of Family, Youth and Community Sciences, University of Florida, Gainesville, FL, United States of America.
Farren BriggsCase Western Reserve University School of Medicine, Cleveland, OH, United States of America; Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America.
Deionte ApplingCase Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Michaela BroadnaxCase Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Carla ConroyCase Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Raechel CooleyUniversity of Cincinnati, College of Medicine, Cincinnati, OH, United States of America.
George EapenDepartment of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America.
Martha SajatovicDepartment of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Case Western Reserve University School of Medicine, Cleveland, OH, United States of America; Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America.
University Hospitals of Cleveland · USCase Western Reserve University · USUniversity of Cincinnati Medical Center · USUniversity School · USCincinnati Children's Hospital Medical Center · USUniversity of Florida · US

Funding

Improving Adherence in Adolescents and Young Adultswith Bipolar DisorderR34MH117206 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI DELBELLO, MELISSA P, SAJATOVIC, MARTHA X · 2019 to 2021
$764k
Customized Treatment Adherence Enhancement in Bipolar DisorderR34MH078967 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI SAJATOVIC, MARTHA X · 2008 to 2010
$634k
NIMH NIH HHS R34 MH078967NIMH NIH HHS R34 MH117206
6 · The paper itself

Abstract

backgroundThe onset of bipolar disorder (BD) is common during late adolescence and young adulthood (AYA). Suboptimal medication adherence is a critical yet modifiable risk factor for negative outcomes among AYAs with BD.

methodsThis research used an iterative process (e.g., focus groups, advisory board, cognitive interviews) to modify an existing adherence intervention to address suboptimal adherence in AYAs with BD. The modified version of Customized Adherence Enhancement for Adolescents and Young Adults (CAE-AYA) will be compared to an Enhanced Treatment as Usual condition (ETAU) in 40 AYAs intervention using a 6-month prospective, randomized controlled trial (RCT) in a high-risk group of 16-21 year old AYAs with BD with demonstrated non-adherence to their prescribed BD medications.

conclusionsThis report describes the methodology and design of the ImprovinG adhereNce In adolescenTs with bipolar disordEr (IGNITE) study. If successful, the CAE-AYA approach has the potential to advance care for vulnerable youth with BD.

Indexed as

Bipolar DisorderAdolescentAdultHumansMedication AdherenceRandomized Controlled Trials as TopicYoung AdultAdherenceAdolescentsBehavioral interventionBipolar disorder

Identifiers

PMID35278693
PMCPMC9022043
OpenAlexW4220662488

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.