ArticleJournal of virological methods2022
Comparison of Abbott ID NOW, a novel isothermal amplification based COVID-19 diagnostic method with RTPCR.
Article in Journal of virological methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- [Implementation of isotermic PCR for detection of SARS-CoV-2 virus].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- A review of current effective COVID-19 testing methods and quality control.Archives of microbiology · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe emergent crisis of the COVID-19 pandemic has posed enormous challenges for clinical laboratories to speed up diagnostics. The current reference standard for the diagnosis of COVID-19 is real time reverse transcriptase PCR on various platforms. However, even with automation, the turnaround time is huge enough to keep up with ever increasing numbers of patients. With increasing surge of COVID cases we need rapid diagnostic tests with good sensitivity and specificity.
objectivesComparison between Abbott ID NOW COVID-19 and real time reverse transcriptase PCR as a reference method. MATERIALS AND
methodsSpecimens from seventy-two individuals were obtained over a period of two months which were processed for ID NOW and RTPCR at a dedicated COVID-19 centre of AIIMS. Dry nasal swabs were used for ID NOW while nasopharyngeal swabs along with throat swab were used for RTPCR. Among the participants, 15 were healthcare workers. Mild COVID was seen in 36 participants, moderate in 19 and severe in 9. Eight participants had non COVID illness.
resultsFrom the given samples, we observed that ID NOW has a sensitivity of 93.22% (55/59) specificity 100% (13/13), PPV 100% (55/55) and NPV 76.47% (13/17).
conclusionID NOW is a convenient, rapid molecular test which makes it suitable for both in laboratory use and as a point of care test. It can be a rapid rule-in test for COVID-19. Negative results, however, have to be interpreted as per the context.
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