ArticleNeuron2022
Neural correlates of blood flow measured by ultrasound.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 84 citations in OpenAlex.
- Trimodal ultrasound imaging of brain-tumor interaction.iScience · 2026Article
- Bayesian-enhanced closed-loop optimization of ultrasound protocols for targeted and precise neuromodulation.bioRxiv : the preprint server for biology · 2026Article
- BOLD signal changes can oppose oxygen metabolism across the human cortex.Nature neuroscience · 2026Article
- Premotor cortex hemodynamic responses primarily reflect perceptual rather than specific motor aspects of decision making.PLoS biology · 2026Article
- Imaging of Neurovascular Activity during Motor Responses Evoked by Displacement-guided Focused Ultrasound (DgFUS) Neuromodulation in Mice.Research square · 2026Article
- Article
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- Microglia Modulate Information Processing in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Opioid-specific brain connectivity dynamics distinguish analgesia from secondary effects: Studies in male mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.Molecular autism · 2026Article
- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
- Mapping function in the tree shrew visual system using functional ultrasound imaging.bioRxiv : the preprint server for biology · 2025Article
- Functional ultrasound neuroimaging reveals mesoscopic organization of saccades in the lateral intraparietal area.Nature communications · 2025Article
- Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Dynamical Modeling of Behaviorally Relevant Spatiotemporal Patterns in Neural Imaging Data.ArXiv · 2025Article
- Exploring Neural Dynamics in the Auditory Telencephalon of Crows Using Functional Ultrasound Imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamical Modeling of Behaviorally Relevant Spatiotemporal Patterns in Neural Imaging Data.Proceedings of machine learning research · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Mobile human brain imaging using functional ultrasound.Science advances · 2025Article
- Isolating single cycles of neural oscillations in population spiking.PLoS computational biology · 2025Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Functional ultrasound imaging (fUSI) is an appealing method for measuring blood flow and thus infer brain activity, but it relies on the physiology of neurovascular coupling and requires extensive signal processing. To establish to what degree fUSI trial-by-trial signals reflect neural activity, we performed simultaneous fUSI and neural recordings with Neuropixels probes in awake mice. fUSI signals strongly correlated with the slow (<0.3 Hz) fluctuations in the local firing rate and were closely predicted by the smoothed firing rate of local neurons, particularly putative inhibitory neurons. The optimal smoothing filter had a width of ∼3 s, matched the hemodynamic response function of awake mice, was invariant across mice and stimulus conditions, and was similar in the cortex and hippocampus. fUSI signals also matched neural firing spatially: firing rates were as highly correlated across hemispheres as fUSI signals. Thus, blood flow measured by ultrasound bears a simple and accurate relationship to neuronal firing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.