Evidence map›Paper›PMID 35278306›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Differential T-Cell Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in mRNA-1273- and BNT162b2-Vaccinated Individuals.

Kathleen M E Gallagher, Mark B Leick, Rebecca C Larson, Trisha R Berger, Katelin Katsis, Jennifer Y Yam, Marcela V Maus

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Frontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathleen M E GallagherImmune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Mark B LeickCellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Rebecca C LarsonCellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Trisha R BergerCellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-3439-3239
Katelin KatsisImmune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jennifer Y YamImmune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Marcela V MausCellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7578-0393

Funding

TRAINING IN TRANSPLANTATION BIOLOGYT32AI007529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1998 to 2024
$6.4M
Overcoming tumor heterogeneity in glioblastoma with multi-targeted CAR T cells secreting bispecific antibodiesR01CA238268 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Marcela Valderrama Maus · 2019 to 2026
$4.0M
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cellsR01CA249062 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAUS, MARCELA VALDERRAMA · 2021 to 2025
$3.5M
Efficacy and immune effects of anakinra prophylaxis for neurologic toxicity and cytokine release syndrome in patients with lymphoma receiving axicabtagene ciloleucelR01CA252940 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAUS, MARCELA VALDERRAMA · 2020 to 2024
$3.4M
NCI NIH HHS R01 CA238268NCI NIH HHS R01 CA249062NCI NIH HHS R01 CA252940NIAID NIH HHS T32 AI007529NIH HHS R01CA238268
6 · The paper itself

Abstract

COVID-19 breakthrough cases among vaccinated individuals demonstrate the value of measuring long-term immunity to SARS-CoV-2 and its variants. We demonstrate that anti-spike T-cell responses and IgG antibody levels are maintained but decrease over time and are lower in BNT162b2- versus mRNA-1273-vaccinated individuals. T-cell responses to the variants are relatively unaffected.

Indexed as

COVID-192019-nCoV Vaccine mRNA-1273Antibodies, ViralBNT162 VaccineBreakthrough InfectionsCOVID-19 VaccinesHumansSARS-CoV-2T-Lymphocytes2019-nCoV Vaccine mRNA-1273Antibodies, ViralBNT162 VaccineCOVID-19 VaccinesBNT162b2mRNA-1273SARS-CoV2 mRNA vaccineT-cell immunityT-cell response

Identifiers

PMID35278306
PMCPMC9402689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.