Evidence map›Paper›PMID 35278268›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Visualizing Proteins in Mammalian Cells by

Wenkai Zhu, Alex J Guseman, Fatema Bhinderwala, Manman Lu, Xun-Cheng Su, Angela M Gronenborn

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Fluorinated Tryptophan Derivatives for Photo-CIDNP NMR.The journal of physical chemistry. B · 2026
    Article
  2. Article
  3. Quantifying Ligand-to-Protein Distances in Complex Environments Using IntermolecularChembiochem : a European journal of chemical biology · 2026
    Article
  4. Article
  5. Analytical chemistry · 2026
    Article
  6. Article
  7. Article
  8. Pushing Sensitivity and Specificity Limits in Native Structural Biology:Journal of the American Chemical Society · 2025
    Article
  9. Article
  10. Rational design ofNature communications · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Perspectives on Applications ofMolecules (Basel, Switzerland) · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Ligand-Based Competition Binding by Real-TimeJournal of medicinal chemistry · 2024
    Article
  20. Enlarging the scenario of site directedScientific reports · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Wenkai ZhuDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.
Alex J GusemanDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.ORCID 0000-0002-9796-5719
Fatema BhinderwalaDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.ORCID 0000-0002-3033-8438
Manman LuDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.ORCID 0000-0002-4156-4975
Xun-Cheng SuState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 300071, Tianjin, China.
Angela M GronenbornDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.ORCID 0000-0001-9072-3525

Funding

Technology Development 2: MAS NMR and dynamic nuclear polarization for HIV-1 structural biologyP50AI150481 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M. · 2019 to 2021
$14.1M
NIAID NIH HHS P50 AI150481NIH HHS P50AI150481
6 · The paper itself

Abstract

In-cell NMR spectroscopy is a powerful tool to investigate protein behavior in physiologically relevant environments. Although proven valuable for disordered proteins, we show that in commonly used

Indexed as

MammalsProteinsAnimalsMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularProtein ConformationProteinsCellular InteractionsFluorine NMR SpectroscopyLine BroadeningParamagnetic Relaxation Enhancement

Identifiers

PMID35278268
PMCPMC9156538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.