Evidence map›Paper›PMID 35278193›Full record

ArticleJournal of molecular neuroscience : MN2022

Brivaracetam Modulates Short-Term Synaptic Activity and Low-Frequency Spontaneous Brain Activity by Delaying Synaptic Vesicle Recycling in Two Distinct Rodent Models of Epileptic Seizures.

Hang Xing, Xiong Han, Sihan Xu, Zhongyu Sun, Shijun Yang

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hang XingDepartment of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, 450000, People's Republic of China.
Xiong HanDepartment of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, 450000, People's Republic of China. hanxiong7589@126.com.ORCID http://orcid.org/0000-0002-3673-1564
Sihan XuKey Lab of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Henan, 453000, People's Republic of China.
Zhongyu SunDepartment of Public Health, Xinxiang Medical University, Henan, 453000, People's Republic of China.
Shijun YangDepartment of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, 450000, People's Republic of China.
Henan University · CNXinxiang Medical University · CN

Funding

Basic and Frontier Technological Project in Henan Province 2015 152300410155Henan Provincial Medical Science and Technology Breakthrough Plan Project 201403136Joint Construction Project of Province and Ministry in Henan Province SB201901074Key Scientific Research Project of Colleges and Universities in Henan Province 17A320028
6 · The paper itself

Abstract

Brivaracetam (BRV) is an anti-seizure drug for the treatment of focal and generalized epileptic seizures shown to augment short-term synaptic fatigue by slowing down synaptic vesicle recycling rates in control animals. In this study, we sought to investigate whether altered short-term synaptic activities could be a pathological hallmark during the interictal periods of epileptic seizures in two well-established rodent models, as well as to reveal BRV's therapeutic roles in altered short-term synaptic activities and low-frequency band spontaneous brain hyperactivity in these models. In our study, the electrophysiological field excitatory post-synaptic potential (fEPSP) recordings were performed in rat hippocampal brain slices from the CA1 region by stimulation of the Schaffer collateral/commissural pathway with or without BRV (30 μM for 3 h) in control or epileptic seizure (induced by pilocarpine (PILO) or high potassium (h-K

Indexed as

AnticonvulsantsSynaptic VesiclesAnimalsBrainFatiguePilocarpinePyrrolidinonesRatsRodentiaSeizuresAnticonvulsantsbrivaracetamPilocarpinePyrrolidinonesAnti-seizure drugsBrivaracetamEpileptic seizuresShort-term synaptic fatigueSV2ASynaptic vesicle recycling

Identifiers

PMID35278193
OpenAlexW4220931036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.