Evidence map›Paper›PMID 35278159›Full record

ArticleBrain imaging and behavior2022

Brain structural changes in regions within the salience network in patients with functional constipation.

Zhenzhen Jia, Guanya Li, Yang Hu, Hao Li, Wenchao Zhang, Jia Wang, Lei Zhang, Zongxin Tan, Shuai Lv, Karen M von Deneen and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Zhenzhen JiaCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Guanya LiCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Yang HuCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Hao LiCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Wenchao ZhangCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Jia WangCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Lei ZhangCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Zongxin TanCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Shuai LvCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Karen M von DeneenCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China.
Shijun DuanDepartment of Radiology, Tangdu Hospital, Air Force Medical University, Xian, 710038, Shaanxi, China.
Guangbin CuiDepartment of Radiology, Tangdu Hospital, Air Force Medical University, Xian, 710038, Shaanxi, China. gbcui@fmmu.edu.cn.
Yi ZhangCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xian, 710071, Shaanxi, China. yizhang@xidian.edu.cn.ORCID http://orcid.org/0000-0003-0859-9735
Yongzhan NieState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xian, 710032, Shaanxi, China. yongznie@fmmu.edu.cn.
Xidian University · CNAir Force Medical University · CNNational Clinical Research Center for Digestive Diseases · CNTang Du Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional constipation (FCon) is one of the common functional gastrointestinal disorders (FGID). Previous studies reported alterations in cortical morphometry as well as changes in white matter (WM) fiber tracts and thalamo-limbic/parietal structural connectivity (SC). However, whether patients with FCon are implicated in changes in gray matter (GM) volume and associated SC remains unclear. Voxel-based morphometry (VBM) was first employed to examine differences in GM volume between 48 patients with FCon and 52 healthy controls (HC). Diffusion tensor imaging (DTI) with probabilistic tractography analysis was then employed to explore alterations in SC of these regions. Results showed abdominal symptoms were positively correlated with anxiety (SAS). Two sample t-test showed patients with FCon had decreased GM volumes in the right middle frontal gyrus (MFG_R), left insula (INS_L), and anterior cingulate cortex (ACC, P

Indexed as

BrainConstipationCase-Control StudiesDiffusion Tensor ImagingGray MatterHumansDiffusion tensor imagingFunctional constipationGray matter volumeSalience networkVoxel-based morphometry

Identifiers

PMID35278159
OpenAlexW4220666073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.