ArticleJournal of neurology2022
The association between cognition and motor performance is beyond structural damage in relapsing-remitting multiple sclerosis.
Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis.Journal of neurology · 2023Trial
- The relationship between cerebellar functional connectivity alterations and hand dexterity impairment in multiple sclerosis.Journal of neurology · 2026Article
- Multimodal predictors of disability progression and processing speed decline in relapsing-remitting multiple sclerosis.Scientific reports · 2025Article
- Validation of the Patient-Determined Disease Steps in ambulatory older adults with multiple sclerosis.Multiple sclerosis and related disorders · 2025Article
- Timed 25-foot walk test is independently associated with cognitive function in multiple sclerosis: a cross-sectional study.European journal of medical research · 2025Article
- Cognitive-motor interference in multiple sclerosis revisited: a dual-task paradigm using wearable inertial sensors and the Paced Auditory Serial Addition Test.Frontiers in neurology · 2025Article
- Digital outcome measures are associated with brain atrophy in patients with multiple sclerosis.Journal of neurology · 2024Article
- Influence of cognition on the correlation between objective and subjective upper limb measures in people with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neuroimaging Technology in Exercise Neurorehabilitation Research in Persons with MS: A Scoping Review.Sensors (Basel, Switzerland) · 2023Article
- The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis.Frontiers in neurology · 2023Article
- Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- An Exploratory Cross-Sectional Study of the Association Between Regular Cigarette Smoking and Level of Disability, Hand Dexterity, Cognitive Impairment, Fatigue, and Markers of Oxidative Stress in Male Patients With Relapsing-Remitting Multiple Sclerosis.American journal of men's healthArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies demonstrated an association between motor and cognitive performance in multiple sclerosis (MS). However, disease-related brain damage might represent a common substrate to both phenomena, which was not considered before.
objectiveAim of this study is to investigate whether the association between cognition and motor function is beyond structural damage in patients with MS.
methodsEighty-one healthy controls and 106 relapsing-remitting (RR) MS patients underwent a 3.0 T MRI with quantification of T2-lesion volumes, T1-lesion volumes and normalized brain volumes. A functional examination [Nine-Hole Peg Test (9-HPT), Timed 25-Foot Walk test (T25FW) and Expanded Disability Status Scale] and a neuropsychological evaluation (Brief Repeatable Battery of Neuropsychological Tests) were also administered. Association between demographic, clinical, cognitive, MRI and functional measures were analysed with univariate analyses and hierarchical linear regression.
resultsIn RRMS patients, Spatial Recall Test and Symbol Digit Modalities Test were positively correlated with 9-HPT (p < 0.001) and T25FW (p ≤ 0.035); Paced Auditory Serial Addition Test (PASAT) correlated with 9-HPT (p ≤ 0.009). 9-HPT and T25FW were significantly associated with normalized brain volumes (p ≤ 0.016), T2- and T1-lesion volumes (p ≤ 0.009). Hierarchical regression models selected age and normalized deep gray matter volume as predictors of T25FW (adjusted-R
conclusionsIn RRMS patients, deficit in information processing speed and executive function may contribute to hand motor dysfunction beyond the effect of structural disease-related burden, supporting the integration of motor and cognitive assessment in clinical settings.
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