Evidence map›Paper›PMID 35277753›Full record

ArticleParasitology research2022

Pharmacokinetic-pharmacodynamic relationships of pour-on administered eprinomectin in nematode-infected lactating female and male castrated dairy breed goats.

Xiuqing Gao, Valerie Kvaternick, Steffen Rehbein, Dietmar Hamel

Open access · hybridAbstract read
In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiuqing GaoFormerly of Boehringer Ingelheim Animal Health USA, Inc., DSD, 631 Route 1 South, North Brunswick, NJ, 08902, USA.
Valerie KvaternickBoehringer Ingelheim Animal Health USA, Inc., DSD, 631 Route 1 South, North Brunswick, NJ, 08902, USA. Valerie.Kvaternick@boehringer-ingelheim.com.ORCID http://orcid.org/0000-0002-5638-0503
Steffen RehbeinBoehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestraße 8-12, 83101, Rohrdorf, Germany.
Dietmar HamelBoehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestraße 8-12, 83101, Rohrdorf, Germany.
Boehringer Ingelheim (Germany) · DEBoehringer Ingelheim (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eprinomectin (EPM), a macrocyclic lactone with low excretion in milk and high efficacy against endoparasites and ectoparasites, is widely used in veterinary medicine. In this paper, EPM pharmacokinetics and anthelmintic efficacy previously established in one study with lactating female goats and three studies with male castrated growing dairy breed goats (all with induced mixed adult gastrointestinal nematode parasitism and treated with a single 1-mg/kg pour-on administration of EPM) were retrospectively evaluated using pharmacokinetic-pharmacodynamic (PK-PD) modeling. The PK-PD analyses between EPM exposure (C

Indexed as

AnthelminticsGoat DiseasesAnimalsFemaleGoatsIvermectinLactationMaleRetrospective StudiesTrichostrongylusAnthelminticseprinomectinIvermectinEprinomectinGoatLactatingPharmacokinetic-pharmacodynamic (PK-PD)

Identifiers

PMID35277753
PMCPMC8993713
OpenAlexW4221078836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.