Trial reportPediatric cardiology2022
Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study).
Trial report in Pediatric cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02550236 (Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Association between NT-proBNP changes and clinical outcomes in paediatric patients with heart failure: Insights from PANORAMA-HF and PARADIGM-HF.ESC heart failure · 2025Trial
- Cardiac Troponin Thresholds in Children and Young Adults: A Multi-Center Cohort Study.The journal of applied laboratory medicine · 2026Observational
- Establishing reference intervals for high-sensitivity cardiac troponin T in neonates and infants.Clinical chemistry and laboratory medicine · 2026Article
- Pediatric heart failure in the era of cardio-immunology: inflammatory-immune context phenotypes, diagnosis, and targeted management.Frontiers in immunology · 2026Review
- Cardiac markers in children and adolescents at the onset of type 1 diabetes mellitus.PloS one · 2026Article
- Association Between High-Sensitivity Troponin (hs-cTnT) and Diagnosis of Myocarditis in Previously Healthy Pediatric Patients.Pediatric cardiology · 2025Article
- Factors associated with NT-proBNP concentration in US children and adolescents: National Health and Nutrition Examination Survey 1999-2004.American heart journal · 2025Article
- Exploring the baseline cardiac function and its correlation with risk stratification in children diagnosed with acute lymphoblastic leukemia.Annals of hematology · 2025Article
- Cardiac Markers in Pediatric Laboratory Medicine: Critical Review.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Elevated levels of NT-proBNP, interferon-γ and tumor necrosis factor-α are associated with coronary artery injury in children with severe Kawasaki disease.American journal of translational research · 2025Article
- Clinical Significance of B-Type Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide in Pediatric Patients: Insights into Their Utility in the Presence or Absence of Pre-Existing Heart Conditions.International journal of molecular sciences · 2024Review
- Specific reference interval for high-sensitivity cardiac troponin I among healthy children in Wuhan, China.Translational pediatrics · 2024Article
- Troponin T is elevated in a relevant proportion of patients with 5q-associated spinal muscular atrophy.Scientific reports · 2024Observational
- Prophylactic Pulmonary Artery Banding in Pediatric Dilated Cardiomyopathy: An Additional Therapeutic Option.Journal of cardiovascular development and disease · 2024Article
- High NT pro-BNP levels in children with malignant disorder receiving intensive fluid treatment: a prospective comparative study.Frontiers in pediatrics · 2024Article
- Global research trends on cardiac troponin and physical activity among pediatric populations: a bibliometric analysis and science mapping study.Frontiers in pediatrics · 2024Article
- Cardiotoxicity of CPX-351 in children and adolescents with relapsed AML: a Children's Oncology Group report.Frontiers in cardiovascular medicine · 2024Article
- Descriptions and Determinants of N-Terminal Pro-B-Type Natriuretic Peptide in Pediatric CKD: The Chronic Kidney Disease in Children (CKiD) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- Influence of growth and metabolic markers on hs-troponin T and NT-proBNP levels in healthy children.Endocrine connections · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to provide reliable pediatric reference values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive Troponin T (hsTnT) obtained from a population of well children and investigate for associations with sex, pubertal status, body mass index (BMI), and serum lipid levels. We analyzed hsTnT and NT-proBNP values obtained from 4826 samples provided by 2522 children aged 0.25-18 years participating in a prospective longitudinal population-based cohort study, "LIFE child" in Leipzig, Germany (Poulain et al., Eur J Epidemiol 32:145-158, 2017). NT-proBNP values decreased throughout childhood from values over 400 ng/L at 3 months to 138 ng/L in females and 65 ng/L in males by 18 years of age. Values dropped rapidly with advancing pubertal stage. We found a strong association between lower NT-proBNP values and higher BMI or elevated serum lipids, the latter effect being more pronounced in males. For hsTnT levels, approximately half of the measurements were below the detection limit. However, 76% of those aged 3 months and 21% of those aged 6 months had values exceeding the adult cut-off limit. Females had slightly higher levels in the first 2 years of life but this was reversed during puberty. In males, there was an upward trend from pubertal stage 2 onward. We identified a positive association between hsTnT and BMI but a negative association with low-density lipoprotein (LDL) cholesterol and triglyceride levels in boys but not in girls. Based on a large number of healthy children, we have established reliable reference values for NT-proBNP and hsTnT for use in everyday clinical practice. We have also identified important associations between certain metabolic and cardiac markers.Clinical Trial Registration ClinicalTrial.gov (NCT02550236).
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Registered trials
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