ArticleNature communications2022
Deep tissue localization and sensing using optical microcavity probes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Massively Multiplexed Photonic Chip With Cross-Channel Fusion For Harmonized Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neural Network-Based Depth Retrieval of Fluorescent Targets From Wide-Field Fluorescence Intensity Images in Scattering Tissues.Journal of biophotonics · 2026Article
- Edible optical microcavities for optical barcoding, authentication, and sensing.Scientific reports · 2026Article
- Two-Photon 3D Printing of Functional Microstructures Inside Living Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Nanometer-Precision Tracking of Adipocyte Dynamics via Single Lipid Droplet Whispering-Gallery Optical Resonances.ACS sensors · 2026Article
- Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Microfluidics-Driven Dripping Technique for Fabricating Polymer Microspheres Doped with AgInSACS omega · 2024Article
- Hyperspectral confocal imaging for high-throughput readout and analysis of bio-integrated microlasers.Nature protocols · 2024Review
- Intracellular biocompatible hexagonal boron nitride quantum emitters as single-photon sources and barcodes.Nanoscale · 2024Article
- Quantifying local stiffness and forces in soft biological tissues using droplet optical microcavities.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Aggregation-Induced Stimulated Emission of 100% Dye Microspheres.Advanced optical materials · 2023Article
- Microcavity- and Microlaser-Based Optical Barcoding: A Review of Encoding Techniques and Applications.ACS photonics · 2023Review
- Glucose-Responsive Boronic Acid Hydrogel Thin Films Obtained via Initiated Chemical Vapor Deposition.Biomacromolecules · 2022Article
- Monitoring Various Bioactivities at the Molecular, Cellular, Tissue, and Organism Levels via Biological Lasers.Sensors (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical microcavities and microlasers were recently introduced as probes inside living cells and tissues. Their main advantages are spectrally narrow emission lines and high sensitivity to the environment. Despite numerous novel methods for optical imaging in strongly scattering biological tissues, imaging at single-cell resolution beyond the ballistic light transport regime remains very challenging. Here, we show that optical microcavity probes embedded inside cells enable three-dimensional localization and tracking of individual cells over extended time periods, as well as sensing of their environment, at depths well beyond the light transport length. This is achieved by utilizing unique spectral features of the whispering-gallery modes, which are unaffected by tissue scattering, absorption, and autofluorescence. In addition, microcavities can be functionalized for simultaneous sensing of various parameters, such as temperature or pH value, which extends their versatility beyond the capabilities of standard fluorescent labels.
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Registered trials
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