ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Prefrontal Cortical Connectivity Mediates Locus Coeruleus Noradrenergic Regulation of Inhibitory Control in Older Adults.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The impact of transcutaneous vagus nerve stimulation on anterior cingulate cortex activity in a cognitive control task.Psychophysiology · 2025Trial
- Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.Nature communications · 2025Article
- Age-Related Increase in Locus Ceruleus Activity and Connectivity with the Prefrontal Cortex during Ambiguity Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review.Biomolecules · 2025Review
- The role of the prefrontal cortex in cocaine-induced noradrenaline release in the nucleus accumbens: a computational study.Biological cybernetics · 2025Article
- Aging disrupts locus coeruleus-driven norepinephrine transmission in the prefrontal cortex: Implications for cognitive and motor decline.Aging cell · 2025Article
- Evidence of physiological changes associated with single-session pre-frontal tDCS: a pilot study.Frontiers in human neuroscience · 2025Article
- Efficacy and safety of guanfacine in hospitalized patients with delirium: A scoping review.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments.Journal of chemical neuroanatomy · 2024Article
- Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer's disease.Alzheimer's research & therapy · 2024Article
- The central executive network moderates the relationship between posttraumatic stress symptom severity and gastrointestinal related issues.Scientific reports · 2024Article
- Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Genotype-by-diagnosis interaction influences self-control in human cocaine addiction.Translational psychiatry · 2023Article
- Locus coeruleus and dorsal cingulate morphology contributions to slowed processing speed.Neuropsychologia · 2023Article
- Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.Scientific reports · 2023Article
- Synergistic effects of transcutaneous vagus nerve stimulation and inhibitory control training on electrophysiological performance in healthy adults.Frontiers in neuroscience · 2023Article
- Cerebrospinal fluid and positron-emission tomography biomarkers for noradrenergic dysfunction in neurodegenerative diseases: a systematic review and meta-analysis.Brain communications · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Response inhibition is a core executive function enabling adaptive behavior in dynamic environments. Human and animal models indicate that inhibitory control and control networks are modulated by noradrenaline, arising from the locus coeruleus. The integrity (i.e., cellular density) of the locus coeruleus noradrenergic system can be estimated from magnetization transfer (MT)-sensitive magnetic resonance imaging (MRI), in view of neuromelanin present in noradrenergic neurons of older adults. Noradrenergic psychopharmacological studies indicate noradrenergic modulation of prefrontal and frontostriatal stopping-circuits in association with behavioral change. Here, we test the noradrenergic hypothesis of inhibitory control, in healthy adults. We predicted that locus coeruleus integrity is associated with age-adjusted variance in response inhibition, mediated by changes in connectivity between frontal inhibitory control regions. In a preregistered analysis, we used MT MRI images from
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.