Evidence map›Paper›PMID 35277357›Full record

ReviewPaediatric respiratory reviews2022

Left behind: The potential impact of CFTR modulators on racial and ethnic disparities in cystic fibrosis.

Meghan E McGarry, Elizabeth R Gibb, Gabriela R Oates, Michael S Schechter

Open access · greenAbstract readReview
In one paragraph

Review in Paediatric respiratory reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Review
  3. Article
  4. Transforming Care Models in Cystic Fibrosis: A Review.Healthcare (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Lentiviral Gene Therapy for Cystic Fibrosis: A Promising Approach and First-in-Human Trial.American journal of respiratory and critical care medicine · 2024
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Meghan E McGarryDivision of Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States.
Elizabeth R GibbDivision of Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States.
Gabriela R OatesDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States.
Michael S SchechterDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, Virginia Commonwealth University and Children's Hospital of Richmond at VCU, Richmond, VA, United States.
University of California, San Francisco · USUniversity of Alabama at Birmingham · USVirginia Commonwealth University · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
Risk Factors For Worse Lung Function In Latinos With Cystic FibrosisK23HL133437 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCGARRY, MEGHAN ELIZABETH · 2018 to 2023
$1.0M
NHLBI NIH HHS K23 HL133437NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

The advent of CFTR modulators, a genomic specific medication, revolutionized the treatment of CF for many patients. However, given that these therapeutics were only developed for specific CFTR mutations, not all people with CF have access to such disease-modifying drugs. Racial and ethnic minority groups are less likely to have CFTR mutations that are approved for CFTR modulators. This exclusion has the potential to widen existing health disparities.

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEthnicityHumansMinority GroupsMutationCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorCFTR modulatorsCystic fibrosisEthnicityRace

Identifiers

PMID35277357
PMCPMC9356388
OpenAlexW4200549882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.