ReviewNutrients2022
A Narrative Review on Pediatric Scurvy: The Last Twenty Years.
Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- A comprehensive review on the co-occurrence of scurvy and anorexia nervosa.Frontiers in nutrition · 2024Pooled it
- Scurvy Masquerading as Malignancy: A Diagnostic Challenge in a Child With Severe Selective Eating.Cureus · 2026Article
- Pediatric Pulmonary Hypertension: A Systematic Approach.JACC. Case reports · 2026Article
- A Case Report of Vitamin C Deficiency Mimicking Osteomyelitis.Pediatric reports · 2026Article
- Pediatric scurvy and eating disorders: the feasibility of a tasteless, odorless multiple-micronutrient powder for avoidance of tube feeding.BioPsychoSocial medicine · 2026Article
- Gait Disturbance Secondary to Scurvy in Patients with ASD and Avoidant/Restrictive Food Intake Disorder (ARFID): Presentation of a Case Series.Journal of autism and developmental disorders · 2026Article
- Article
- Vitamin C Deficiency Presenting with Progressive Gait Difficulty, Myopathy, and Movement Disorder in a Toddler.Movement disorders clinical practice · 2025Article
- The role of vitamin C on the skin.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025Review
- Role of Nutritional Elements in Skin Homeostasis: A Review.Biomolecules · 2025Review
- Scurvy, all the faces you can see: our experience and review of the literature.Italian journal of pediatrics · 2025Review
- Hip Involvement in Pediatric Scurvy: Early Magnetic Imaging Signs.Children (Basel, Switzerland) · 2025Article
- The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review.Dentistry journal · 2025Review
- Article
- Prevalence of Obesity Among Elementary School Children in Cyprus: The National COSI Program.Nutrients · 2025Article
- Rising incidence of paediatric scurvy - patient database querying does not reveal the whole story - authors' reply.The Lancet regional health. Europe · 2025Article
- Rising incidence of paediatric scurvy-patient database querying does not reveal the whole story.The Lancet regional health. Europe · 2025Article
- Scurvy incidence trend among children hospitalised in France, 2015-2023: a population-based interrupted time-series analysis.The Lancet regional health. Europe · 2025Article
- Case Report: Autistic child with restrictive eating behaviour, limping gait and erythematous gingival mass-scurvy?Frontiers in child and adolescent psychiatry · 2025Article
- Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review.Open medicine (Warsaw, Poland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scurvy is a well-known clinical condition caused by vitamin C deficiency. Although considered a rare disease in high-income countries, it has been recently increasingly reported in children, especially in those with abnormal dietary habits, mental or physical disabilities. We performed an extensive review of the literature analyzing studies published in the last 20 years focusing on clinical features, differential diagnosis and diagnostic delay. Fifteen articles were selected, collectively reporting a total of 166 children. Because of the wide clinical spectrum (musculoskeletal complaints and/or mucocutaneous lesions or systemic symptoms), scurvy can mimic several conditions, including autoimmune diseases, infections, and neoplasia. In addition, frequent findings such as normal nutritional status, anemia or elevated inflammatory markers may guide clinicians towards the abovementioned misdiagnoses. Scurvy should be considered in patients presenting with musculoskeletal complaints, not only in those with risk factors but also in healthy children. A focused dietary history and a careful physical examination, assessing other signs of vitamin C deficiency, are mandatory in these patients. When suspected, the dosage of serum vitamin C is the diagnostic gold standard; furthermore, imaging studies, performed by an expert radiologist, can reveal the typical features of scurvy. Only early diagnosis can avoid unnecessary investigations and potentially fatal complications of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.