ReviewNutrients2022
Nutraceuticals: A New Challenge against Cadmium-Induced Testicular Injury.
Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The ameliorate effect of 18-beta glycyrrhetinic acid against cadmium-induced reproductive damage.Journal of molecular histology · 2026Article
- Green chemistry for prostate health: exploring nature's toolbox against cancer, inflammation, and hyperplasia.Molecular diversity · 2026Review
- Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney.Journal of advanced research · 2026Article
- Environmental determinants of male infertility: emerging threats and technological interventions.Frontiers in medicine · 2026Review
- Integrated Transcriptomic and Metabolomic Analysis Reveals Regulatory Effects of Fermented Chinese Chive on Early Testicular Development in Piglets.Antioxidants (Basel, Switzerland) · 2025Article
- Safranal Alleviates Cyclophosphamide Induced Testicular Toxicity in Rats.Food science & nutrition · 2025Article
- Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.Cell death discovery · 2025Review
- Early Zinc Supplementation Enhances Epididymal Sperm Glycosylation, Endocrine Activity, and Antioxidant Activity in Rats Exposed to Cadmium.International journal of molecular sciences · 2025Article
- Potential therapeutic effects of shrimp protein hydrolysates on NAFLD-induced infertility disorders: Insights into redox balance, heat shock protein expression, and chromatin compaction in male rats.Iranian journal of basic medical sciences · 2025Article
- Review
- Effects of Heat Stress-Induced Sex Hormone Dysregulation on Reproduction and Growth in Male Adolescents and Beneficial Foods.Nutrients · 2024Review
- The Effects of Seleno-Methionine in Cadmium-Challenged Human Primary Chondrocytes.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The role of red ginseng in men's reproductive health: a literature review.Basic and clinical andrology · 2023Review
- Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation.Molecular biology reports · 2023Article
- N-Acetylcysteine Displaces Glutathionyl-Moieties from HgMolecules (Basel, Switzerland) · 2023Article
- Nutraceuticals as Alternative Approach against Cadmium-Induced Kidney Damage: A Narrative Review.Metabolites · 2023Review
- Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway.Aging · 2023Article
- Diet and Fertility Status: Relevance in Health and Disease.Nutrients · 2023Article
- Structural Characterization of aNutrients · 2022Article
- Beneficial Effect of Methanolic Extract of Frankincense (Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) is a widespread heavy metal and a ubiquitous environmental toxicant. For the general population, the principal causes of Cd exposure are cigarette smoking, air pollution and contaminated water and food consumption, whereas occupational exposure usually involves humans working in mines or manufacturing batteries and pigments that utilize Cd. The aim of the present review is to evaluate recent data regarding the mechanisms of Cd-induced testicular structural and functional damages and the state of the art of the therapeutic approaches. Additionally, as the current literature demonstrates convincing associations between diet, food components and men's sexual health, a coherent nutraceutical supplementation may be a new valid therapeutic strategy for both the prevention and alleviation of Cd-induced testicular injury. The toxic effects on testes induced by Cd include many specific mechanisms, such as oxidative stress, inflammation and apoptosis. As no specific therapy for the prevention or treatment of the morbidity and mortality associated with Cd exposure is available, the development of new therapeutic agents is requested. Dietary strategies and the use of nutraceuticals, particularly abundant in fresh fruits, beans, vegetables and grains, typical of the Mediterranean diet, are recommended against Cd-induced testicular injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.