Evidence map›Paper›PMID 35276979›Full record

ReviewNutrients2022

The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?

Zahra Ilyas, Simone Perna, Tariq A Alalwan, Muhammad Nauman Zahid, Daniele Spadaccini, Clara Gasparri, Gabriella Peroni, Alessandro Faragli, Alessio Alogna, Edoardo La Porta and 5 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05841173 (Effects of Weight Loss Management on Cognitive Function in Elderly Obese Women), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05841173 naunknown statusnot on this map

Effects of Weight Loss Management on Cognitive Function in Elderly Obese Women

TypeinterventionalSponsorFederal State Budgetary Scientific InstitutionRan2022 to 2023Enrolled200ConditionsObesity, Cognitive ChangeArms"PanTrek", Physical Trainings, Placebo, Diet
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Zahra IlyasDepartment of Laboratory, Bahrain Specialist Hospital, Juffair P.O. Box 10588, Bahrain.ORCID 0000-0002-2038-4449
Simone PernaDepartment of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.ORCID 0000-0002-2720-1473
Tariq A AlalwanDepartment of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.ORCID 0000-0002-7693-4542
Muhammad Nauman ZahidDepartment of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.ORCID 0000-0002-8322-9294
Daniele SpadacciniEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-6413-9253
Clara GasparriEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-1088-6648
Gabriella PeroniEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-1632-1787
Alessandro FaragliDepartment of Internal Medicine/Cardiology, Deutsches Herzzentrum Berlin, 13353 Berlin, Germany.
Alessio AlognaDepartment of Internal Medicine and Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Edoardo La PortaDepartment of Cardionephrology, Istituto Clinico Ligure Di Alta Specialità (ICLAS), GVM Care and Research, 16035 Rapallo, Italy.
Ali Ali RedhaDepartment of Chemistry, College of Science, Sakhir Campus, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.ORCID 0000-0002-9665-9074
Massimo NegroCRIAMS-Sport Medicine Centre, 27058 Voghera, Italy.ORCID 0000-0002-9159-9287
Giuseppe CerulloDepartment of Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Napoli, Italy.ORCID 0000-0001-8098-2283
Giuseppe D'AntonaCRIAMS-Sport Medicine Centre, 27058 Voghera, Italy.
Mariangela RondanelliDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-8336-4851
University of Bahrain · BHUniversity of Pavia · ITDeutsches Herzzentrum der Charité · DEGerman Centre for Cardiovascular Research · DEParthenope University of Naples · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review aims to define the effectiveness of the ketogenic diet (KD) for the management of sarcopenic obesity. As the combination of sarcopenia and obesity appears to have multiple negative metabolic effects, this narrative review discusses the effects of the ketogenic diet as a possible synergic intervention to decrease visceral adipose tissue (VAT) and fatty infiltration of the liver as well as modulate and improve the gut microbiota, inflammation and body composition. The results of this review support the evidence that the KD improves metabolic health and expands adipose tissue γδ T cells that are important for glycaemia control during obesity. The KD is also a therapeutic option for individuals with sarcopenic obesity due to its positive effect on VAT, adipose tissue, cytokines such as blood biochemistry, gut microbiota, and body composition. However, the long-term effect of a KD on these outcomes requires further investigations before general recommendations can be made.

Indexed as

Diet, KetogenicGastrointestinal MicrobiomeSarcopeniaBody CompositionHumansObesitycytokinefatty livergut microbiotaketogenic dietphysical inactivitysarcopeniavisceral adipose tissue (VAT)

Identifiers

PMID35276979
PMCPMC8838342
OpenAlexW4210497197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.