Evidence map›Paper›PMID 35276828›Full record

Observational studyNutrients2022

Simple Nutrient-Based Rules vs. a Nutritionally Rich Plant-Centered Diet in Prediction of Future Coronary Heart Disease and Stroke: Prospective Observational Study in the US.

Yuni Choi, Daniel D Gallaher, Karianne Svendsen, Katie A Meyer, Lyn M Steffen, Pamela J Schreiner, James M Shikany, Jamal S Rana, Daniel A Duprez, David R Jacobs

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yuni ChoiDivision of Epidemiology and Community Health, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
Daniel D GallaherDepartment of Food Science and Nutrition, University of Minnesota-Twin Cities, Saint Paul, MN 55108, USA.ORCID 0000-0002-5969-4938
Karianne SvendsenDepartment of Nutrition, University of Oslo, 0317 Oslo, Norway.ORCID 0000-0002-7628-0999
Katie A MeyerDepartment of Nutrition and Nutrition Research Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 28081, USA.
Lyn M SteffenDivision of Epidemiology and Community Health, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Jamal S RanaDivisions of Cardiology and Research, Kaiser Permanente Northern California, Department of Medicine, University of California, Oakland, CA 94612, USA.
Daniel A DuprezCardiovascular Division, Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.ORCID 0000-0002-0993-6839
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
University of Minnesota · USKaiser Permanente · USOslo University Hospital · NOUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · US

Funding

NIH HHS HHSN268201800005I; HHSN268201800007I; HHSN268201800003I; HHSN268201800006I; HHSN268201800004I
6 · The paper itself

Abstract

To better understand nutrition paradigm shift from nutrients to foods and dietary patterns, we compared associations of a nutrient-based blood cholesterol-lowering diet vs. a food-based plant-centered diet with risk of coronary heart disease (CHD) and stroke. Participants were 4701 adults aged 18-30 years and free of cardiovascular disease at baseline, followed for clinical events from 1985 and 86 to 2018. A plant-centered diet was represented by higher A Priori Diet Quality Score (APDQS). A blood cholesterol-lowering diet was represented by lower Keys Score. Proportional hazards regression was used to calculate hazard ratios (HR). Higher APDQS showed a nutrient-dense composition that is low in saturated fat but high in fiber, vitamins and minerals. Keys Score and APDQS changes were each inversely associated with concurrent plasma low-density lipoprotein cholesterol (LDL-C) change. Over follow-up, 116 CHD and 80 stroke events occurred. LDL-C predicted CHD, but not stroke. APDQS, but not Keys Score, predicted lower risk of CHD and of stroke. Adjusted HRs (95% CIs) for each 1-SD higher APDQS were 0.73 (0.55-0.96) for CHD and 0.70 (0.50-0.99) for stroke. Neither low dietary fat nor low dietary carbohydrate predicted these events. Our findings support the ongoing shift in diet messages for cardiovascular prevention.

Indexed as

Coronary DiseaseStrokeAdolescentAdultDiet, Fat-RestrictedHumansNutrientsProspective StudiesYoung AdultNutrientscholesterol-lowering dietscoronary heart diseaseplant-centered dietsprospective studysimple nutrient-based rulesstroke

Identifiers

PMID35276828
PMCPMC8837984
OpenAlexW4206979543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.