ArticleNutrients2022
Dietary Copper Intake and Risk of Stroke in Adults: A Case-Control Study Based on National Health and Nutrition Examination Survey 2013-2018.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Cuproptosis in Ischemic Stroke: Molecular Mechanisms and Therapeutic Potential.Molecules (Basel, Switzerland) · 2026Review
- Article
- The Yin and Yang of copper in cardiovascular health and disease.Molecular and cellular biochemistry · 2026Review
- Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review).International journal of molecular medicine · 2026Review
- Multi-omics integration identifies ARID1B linking cuproptosis-immune crosstalk with atherosclerotic plaque progression.Frontiers in genetics · 2026Article
- Metallomic Aspects of Stroke and Recovery: ICP-MS Study with Chemometric Analysis.Molecules (Basel, Switzerland) · 2025Article
- Article
- Oxidative stress indicators mediated the association of dietary copper intake with low muscle mass: a cross-sectional study.NPJ science of food · 2025Article
- Interaction effects of dietary carotenoid intake and gamma-glutamyl transferase level on the prevalence of stroke in older adults.Journal of health, population, and nutrition · 2025Observational
- Serum copper modulates cognitive function in diabetic patients via an HDL-C-mediated pathway: identification of a 25 µg/dL exploratory threshold.Diabetology & metabolic syndrome · 2025Article
- The Associations of Dietary Copper and Magnesium Intake, Geriatric Nutritional Risk Index, and Systemic Inflammation Response Index with Stroke Risk in the ElderlyBalkan medical journal · 2025Article
- Monocyte-to-albumin ratio outperforms triglyceride-glucose index in associating with stroke prevalence among diabetics: an NHANES cross-sectional study.European journal of medical research · 2025Article
- Copper Intake and Mortality Among Asthmatic Adults: A Cohort Study.Biological trace element research · 2025Article
- Occurrence of Potentially Toxic Metals Detected in Milk and Dairy Products in Türkiye: An Assessment in Terms of Human Exposure and Health Risks.Foods (Basel, Switzerland) · 2025Article
- Association between dietary copper intake and cognitive function in American older adults: NHANES 2011-2014.Scientific reports · 2025Observational
- Chronic Copper Overload Triggers Inflammation in Mesenteric PVAT Alongside Changes in Renin-Angiotensin System-Related Pathways.Nutrients · 2025Article
- Dietary zinc intake associated with stroke in American adults.Scientific reports · 2025Article
- Dietary Riboflavin Intake and the Risk of Stroke: Insights From NHANES 2007-2018.Food science & nutrition · 2025Article
- Copper Impedes Calcification of Human Aortic Vascular Smooth Muscle Cells Through Inhibition of Osteogenic Transdifferentiation and Promotion of Extracellular Matrix Stability.Journal of cellular physiology · 2025Article
- Associations of Naples prognostic score with stroke in adults and all cause mortality among stroke patients.Scientific reports · 2025Article
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4 authors.
Funding
Abstract
The association between dietary copper intake and the risk of stroke is unknown. We included a total of 10,550 participants from the National Health and Nutrition Examination Survey (NHANES) 2013−2018. Two 24-h dietary recalls and a standard questionnaire were used to determine copper intake and stroke, respectively. We used logistic regression models to estimate the associations between dietary copper intake and the risk of stroke. The nearest-neighbor propensity score matching (PSM) with a ratio of 1:2 was used to reduce selection bias. The non-linear relationship was explored with restricted cubic splines (RCS). The correlation between copper intake and baseline characteristics was detected by the Pearson correlation coefficient. The median dietary copper intake was 1.072 mg/day (IQR = 1.42−0.799). Approximately 3.8% (399) of the participants had a history of stroke. A multivariate logistic regression analysis before and after matching showed that subjects in the higher quartile had significantly lower odds of stroke compared with subjects in the first quartile of copper intake. A stratified analysis showed that copper intake was a significant protective factor for women, individuals <65 years old, individuals with hypertension, individuals who smoke, and diabetic stroke patients. The RCS models showed an L-shaped nonlinear relationship (p for nonlinear < 0.001) between copper intake and stroke. Our results suggested that increased dietary copper intake was associated with a lower risk of stroke.
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