Evidence map›Paper›PMID 35276587›Full record

ArticleJournal of autoimmunity2022

Impaired central tolerance induces changes in the gut microbiota that exacerbate autoimmune hepatitis.

Monica Centa, Erica G Weinstein, Jose C Clemente, Jeremiah J Faith, M Isabel Fiel, Robby Lyallpuri, Olivier Herbin, Konstantina Alexandropoulos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Monica CentaDepartment of Medicine, Division of Clinical Immunology, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Erica G WeinsteinFlagship Pioneering, Cambridge, MA, USA.
Jose C ClementeDepartment of Medicine, Division of Clinical Immunology, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeremiah J FaithDepartment of Medicine, Division of Clinical Immunology, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M Isabel FielDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robby LyallpuriDepartment of Medicine, Division of Clinical Immunology, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Olivier HerbinRegeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Konstantina AlexandropoulosDepartment of Medicine, Division of Clinical Immunology, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: k.alexandropoulos@mssm.edu.
Icahn School of Medicine at Mount Sinai · USFlagship Pioneering (United States) · USRegeneron (United States) · US

Funding

Microbiota-mediated T cell tolerance in newborn and adult autoimmunity-prone miceR01AI144903 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALEXANDROPOULOS, KONSTANTINA · 2019 to 2023
$2.3M
Role of Chat-H in chemokine-induced T lymphocyte migration and traffickingR01AI068963 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALEXANDROPOULOS, KONSTANTINA · 2007 to 2011
$2.2M
Mechanism of autoimmune hepatitis development in a novel mouse modelR01DK107992 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALEXANDROPOULOS, KONSTANTINA · 2016 to 2020
$1.9M
The relationship between host diet, the gut microbiota, and host transcriptionR01GM108505 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAITH, JEREMIAH JAMES · 2014 to 2017
$1.7M
Role of the thymic epithelium on the outcome of allogeneic transplantationR01AI088106 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALEXANDROPOULOS, KONSTANTINA · 2011 to 2014
$1.7M
Optimized identification of therapeutic bacterial strains in ulcerative colitisR01DK114038 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLEMENTE, JOSE C · 2018 to 2020
$762k
Mechanism of autoimmune hepatitis development in a novel mouse modelR56DK107992 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALEXANDROPOULOS, KONSTANTINA · 2015 to 2015
$271k
NIAID NIH HHS R01 AI068963NIAID NIH HHS R01 AI088106NIAID NIH HHS R01 AI144903NIDDK NIH HHS R01 DK107992NIDDK NIH HHS R01 DK114038NIDDK NIH HHS R56 DK107992NIGMS NIH HHS R01 GM108505
6 · The paper itself

Abstract

Medullary thymic epithelial cells (mTECs) induce T cell tolerance in the thymus through the elimination of self-reactive thymocytes. Commensal bacteria are also critical for shaping T cell responses in the gut and distal organs. We previously showed that mice depleted of mTECs (Traf6ΔTEC) generated autoreactive T cells and developed autoimmune hepatitis (AIH). In this report, we found that Toll-like receptor (TLR)-mediated microbial sensing on liver hematopoietic cells and the gut microbiota contributed to AIH development in Traf6ΔTEC mice. While adoptive transfer of thymic Traf6ΔTEC T cells in immune-deficient mice was sufficient for AIH development, colonization of germ-free mice with Traf6ΔTEC microbiota failed to induce AIH, suggesting that the gut microbiota contributes to but is not sufficient for AIH development. Microbiota-mediated exacerbation of AIH associated with increased numbers of hepatic Foxp3

Indexed as

Gastrointestinal MicrobiomeHepatitis, AutoimmuneAnimalsCentral ToleranceMiceMice, Inbred C57BLThymus GlandT-Lymphocytes, RegulatoryAutoimmune hepatitisCentral toleranceFoxp3 T regulatory CellsGut microbiotaMedullary thymic epithelial cellsToll-like receptors

Identifiers

PMID35276587
PMCPMC8963681
OpenAlexW4221048792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.