Evidence map›Paper›PMID 35276219›Full record

ArticleCryobiology2022

Supplemented phase diagrams for vitrification CPA cocktails: DP6, VS55 and M22.

Z Han, L Gangwar, E Magnuson, M L Etheridge, C O Pringle, J C Bischof, J Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cryobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Lessons From Drug Discovery for Cryoprotective Agent Design: An AI-Oriented Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Conduction-Dominated Cryomesh for Organism Vitrification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Z HanDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
L GangwarDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
E MagnusonDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
M L EtheridgeDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
C O PringleDepartment of Engineering Technologies, Safety, and Construction, Central Washington University, 400 E. University Way, Ellensburg, WA, 98926, USA.
J C BischofDepartment of Mechanical Engineering, Department of Biomedical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA. Electronic address: jeunghwan.choi@cwu.edu.
J ChoiDepartment of Engineering Technologies, Safety, and Construction, Central Washington University, 400 E. University Way, Ellensburg, WA, 98926, USA. Electronic address: bischof@umn.edu.

Funding

Organ banking for transplant—kidney cryopreservation by vitrification and novel nanowarming technologyR01DK117425 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2018 to 2026
$4.9M
Breakthrough Tissue and Organ Preservation and Transplantation Using Scaled-Up Nanowarming TechnologyR01HL135046 · NHLBI · UNIVERSITY OF MINNESOTA · PI BISCHOF, JOHN C, FINGER, ERIK BRIAN · 2017 to 2020
$2.6M
NHLBI NIH HHS R01 HL135046NIDDK NIH HHS R01 DK117425
6 · The paper itself

Abstract

DP6, VS55 and M22 are the most commonly used cryoprotective agent (CPA) cocktails for vitrification experiments in tissues and organs. However, complete phase diagrams for the three CPAs are often unavailable or incomplete (only available for full strength CPAs) thereby hampering optimization of vitrification and rewarming procedures. In this paper, we used differential scanning calorimetry (DSC) to measure the transition temperatures including heterogeneous nucleation temperatures (T

Indexed as

Cryoprotective AgentsVitrificationCalorimetry, Differential ScanningCryopreservationFreezingCryoprotective AgentsDP6M22Phase diagramVitrificationVS55

Identifiers

PMID35276219
PMCPMC10202161

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.