ArticleGastrointestinal endoscopy2022
Clinically significant serrated polyp detection rates and risk for postcolonoscopy colorectal cancer: data from the New Hampshire Colonoscopy Registry.
Article in Gastrointestinal endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07127471 (A Multicenter Prospective Randomized Controlled Trial of Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions in Computer-Aided Water Exchange Colonoscopy), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Prospective Randomized Controlled Trial of Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions in Computer-Aided Water Exchange Colonoscopy
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative Performance of Artificial Intelligence-Based Computer-Aided Detection Systems for Colorectal Polyps: A Systematic Review and Network Meta-Analysis.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Pooled it
- Quality indicators for colonoscopy.Gastrointestinal endoscopy · 2024Guideline
- Evaluation of serrated lesion detection using different indicators: a single-centre, community-based, retrospective cohort study.BMJ open gastroenterology · 2026Article
- Higher Sessile Serrated Lesion Detection Rates Calculated Using All Examinations Are Associated With Lower Risk for Postcolonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry.Clinical and translational gastroenterology · 2026Article
- Sessile Serrated Lesion Detection Rate and Colorectal Cancer Risk and Mortality.JAMA network open · 2026Article
- Pragmatic Implementation Study of a Computer-Aided Detection Device on Colonoscopy Outcomes at a Trainee-Dominated Academic County Hospital.Digestive diseases and sciences · 2026Article
- Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records.The American journal of pathology · 2026Article
- Colonoscopy Quality and Strategies for Improvement.Gut and liver · 2026Review
- Mixed lesions in premalignant colorectal polyps.Journal of clinical biochemistry and nutrition · 2026Article
- A novel cloud-based artificial intelligence for real-time detection of colorectal neoplasia - a randomized controlled trial (EAGLE).NPJ digital medicine · 2025Article
- Serrated polyps in the colorectum: clinical significance and future directions.BMJ open gastroenterology · 2025Review
- Extracellular Vesicles as a Platform for Predicting Cancer Risk in Patients with Adenomas and Polyps of the Colon with Obesity.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Traditional and Novel Colonoscopy Quality Metrics: What's Important in 2025.Current gastroenterology reports · 2025Review
- Advantages of new generation colonoscopes on adenoma detection: A propensity-score matching study.World journal of gastrointestinal endoscopy · 2025Article
- Variation in Proximal Sessile Serrated Lesion Detection Rates During Non-screening Colonoscopies.Cureus · 2025Article
- Post-colonoscopy colorectal cancer and the association with endoscopic findings in the Danish colorectal cancer screening programme.BMJ open gastroenterology · 2025Article
- Submucosal fibrosis in large colorectal serrated lesions in cases receiving endoscopic submucosal dissection.Therapeutic advances in gastroenterology · 2025Article
- Association Between Longer Cecal Intubation Time and Detection and Miss Rate of Colorectal Neoplasms.Journal of clinical medicine · 2024Article
- Association of Endoscopist Colonoscopy Quality Measures With Follow-Up Colonoscopy Outcomes After Positive Stool Tests (Multitarget Stool DNA or Fecal Immunochemical Test): Retrospective Cross-Sectional Analysis of Data From the New Hampshire Colonoscopy Registry.The American journal of gastroenterology · 2024Article
- Which is the better polyp detection metric: adenomas per colonoscopy or adenoma detection rate? A simulation modeling study.Endoscopy international open · 2024Article
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7 authors.
Funding
Abstract
BACKGROUND AND
aimsHigher adenoma detection rates reduce the risk of postcolonoscopy colorectal cancer (PCCRC). Clinically significant serrated polyps (CSSPs; defined as any sessile serrated polyp, traditional serrated adenoma, large [≥1 cm] or proximal hyperplastic polyp >5 mm) also lead to PCCRC, but there are no data on associated CSSP detection rates (CSSDRs). We used data from the New Hampshire Colonoscopy Registry (NHCR) to investigate the association between PCCRC risk and endoscopist CSSDR.
methodsWe included NHCR patients with 1 or more follow-up events: either a colonoscopy or a colorectal cancer (CRC) diagnosis identified through linkage with the New Hampshire State Cancer Registry. We defined our outcome, PCCRC, in 3 time periods: CRC diagnosed 6 to 36 months, 6 to 60 months, or all examinations (6 months or longer) after an index examination. We excluded patients with CRC diagnosed at or within 6 months of the index examination, with incomplete examinations, or with inflammatory bowel disease. The exposure variable was endoscopist CSSDR at the index colonoscopy. Cox regression was used to model the hazard of PCCRC on CSSDR controlling for age, sex, index findings, year of examination, personal history of colorectal neoplasia, and having more than 1 surveillance examination.
resultsOne hundred twenty-eight patients with CRC diagnosed at least 6 months after their index examination were included. Our cohort included 142 endoscopists (92 gastroenterologists). We observed that the risk for PCCRC 6 months or longer after the index examination was significantly lower for examinations performed by endoscopists with CSSDRs of 3% to <9% (hazard ratio [HR], .57; 95% confidence interval [CI], .39-.83) or 9% or higher (HR, .39; 95% CI, .20-.78) relative to those with CSSDRs under 3%.
conclusionsOur study is the first to demonstrate a lower PCCRC risk after examinations performed by endoscopists with higher CSSDRs. Both CSSDRs of 9% and 3% to <9% had statistically lower risk of PCCRC than CSSDRs of <3%. These data validate CSSDR as a clinically relevant quality measure for endoscopists.
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