Evidence map›Paper›PMID 35276204›Full record

ArticleKidney international2022

Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium.

Bilal A Naved, Joseph V Bonventre, Jeffrey A Hubbell, Neil A Hukriede, Benjamin D Humphreys, Carl Kesselman, M Todd Valerius, Andrew P McMahon, Stuart J Shankland, Jason A Wertheim and 3 more

Abstract read
In one paragraph

Article in Kidney international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Targeting a Novel AREGCell proliferation · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Biology of the proximal tubule in body homeostasis and kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  14. Article
  15. Review
  16. Systemic and Cardiac Microvascular Dysfunction in Hypertension.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bilal A NavedMedical Science Training Program, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Joseph V BonventreDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jeffrey A HubbellPritzker School of Molecular Engineering, The University of Chicago, Chicago, Illinois, USA.
Neil A HukriedeDepartment of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Benjamin D HumphreysDepartment of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Carl KesselmanInformatics Systems Research Division, Information Sciences Institute, University of Southern California, Los Angeles, California, USA.
M Todd ValeriusDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, W.M. Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Stuart J ShanklandDivision of Nephrology, University of Washington School of Medicine, Seattle, Washington, USA.
Jason A WertheimDepartment of Biomedical Engineering, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Michael J V WhitePritzker School of Molecular Engineering, The University of Chicago, Chicago, Illinois, USA.
Mark P de CaesteckerDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Iain A DrummondDavis Center for Regenerative Biology and Aging, Mount Desert Island Biological Laboratory, Bar Harbor, Maine, USA. Electronic address: idrummond@mdibl.org.

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
The USC (Re)Building the Kidney Coordinating CenterU01DK107350 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL, VALERIUS, MICHAEL TODD · 2015 to 2019
$9.0M
Mechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2M
Regulation of Renal Progenitor Cells in Regenerating KidneysR01DK069403 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUKRIEDE, NEIL A · 2006 to 2020
$4.8M
Cell specific delivery of novel therapies to enhance glomerular regeneration and repairUC2DK126006 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2020 to 2024
$4.0M
Single-cell analysis to promote kidney repairUC2DK126024 · NIDDK · WASHINGTON UNIVERSITY · PI HUMPHREYS, BENJAMIN D., KIM, JUNHYONG · 2020 to 2024
$3.7M
Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUH3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2019 to 2021
$3.3M
Therapeutic Optimization of Productive Repair After Acute Kidney InjuryUC2DK126122 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIDSON, ALAN, DE CAESTECKER, MARK P. · 2020 to 2024
$3.2M
Identifying pathways required for integration of kidney organoid and host epitheliaUC2DK126021 · NIDDK · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A., MARCIANO, DENISE K · 2020 to 2024
$3.1M
Mechanisms and therapeutic manipulation of retinoic acid signaling in Acute Kidney InjuryR01DK112688 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2020
$1.7M
BLRD VA I01 BX002660NCATS NIH HHS UH3 TR002155NIDDK NIH HHS DP3 DK108215NIDDK NIH HHS F30 DK123985NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK039773NIDDK NIH HHS R01 DK069403NIDDK NIH HHS R01 DK112688NIDDK NIH HHS R01 DK113168NIDDK NIH HHS U01 DK107350NIDDK NIH HHS UC2 DK126006NIDDK NIH HHS UC2 DK126021NIDDK NIH HHS UC2 DK126024NIDDK NIH HHS UC2 DK126122NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies promote development of therapeutics? Also, we provide a guide to RBK's open access data hub for accessing, downloading, and further analyzing data sets.

Indexed as

Acute Kidney InjuryKidneyFemaleFibrosisHumansInflammationMaleNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.)RegenerationUnited Statesacute kidney injurycell signalingfibrosisglomerulusinflammationproximal tubule

Identifiers

PMID35276204
PMCPMC9045003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.