ArticleEnvironmental research2022
Domain-specific effects of prenatal fluoride exposure on child IQ at 4, 5, and 6-12 years in the ELEMENT cohort.
Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Global groundwater contamination by geogenic fluoride.Environmental geochemistry and health · 2026Pooled it
- Fluoride and Neurodevelopmental Hazard Modelling: An Assessment of Concentration-Response Analysis.Community dentistry and oral epidemiology · 2026Pooled it
- Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2025Pooled it
- Article
- Psychometric Evaluation of the Naglieri Nonverbal Ability Test (NNAT-I) in Turkish Middle School Students Aged 10-14 Years.Journal of Intelligence · 2026Article
- Relationships between Toenail, Urinary, and Drinking-water Fluoride Concentrations in a Pregnancy Cohort using Private Water Systems in the United States.Biological trace element research · 2026Article
- Article
- International fluoride symposium: effects of fluoride on human health and its mechanisms of action - a meeting report.BMC proceedings · 2025Article
- Updated consumer risk assessment of fluoride in food and drinking water including the contribution from other sources of oral exposure.EFSA journal. European Food Safety Authority · 2025Article
- How the public's knowledge, attitudes, and practice intersect with scientific evidence about fluoride.Current problems in pediatric and adolescent health care · 2025Article
- Tooth decay prevention and neurodevelopmental disorder risk following childhood fluoride exposure.BMC pediatrics · 2025Article
- Prenatal and Childhood Exposure to Fluoride and Cognitive Development: Findings from the Longitudinal MINIMat Cohort in Rural Bangladesh.Environmental health perspectives · 2025Article
- Correlation of fluoride intake with haemoglobin level and intelligence quotient in 8-12 year aged children: an observational study from India.BMC public health · 2025Observational
- Fluoride Induces Neurocytotoxicity by Disrupting Lysosomal Iron Metabolism and Membrane Permeability.Biological trace element research · 2025Article
- Fluoride content in table salt from the Element Project in Mexico City.Salud publica de Mexico · 2024Article
- Maternal Urinary Fluoride and Child Neurobehavior at Age 36 Months.JAMA network open · 2024Article
- Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.European journal of public health · 2024Article
- Urinary fluoride levels and metal co-exposures among pregnant women in Los Angeles, California.Environmental health : a global access science source · 2023Article
- Association of Dental Fluorosis and Urinary Fluoride with Intelligence among Schoolchildren.Children (Basel, Switzerland) · 2023Article
- A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment.Advances in nutrition (Bethesda, Md.) · 2023Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivePrenatal exposure to fluoride has been associated with adverse neurodevelopmental outcomes. However, the neuropsychological profile of fluoride's developmental neurotoxicity at low levels and the stability of this relationship across childhood has not been characterized. We investigated the longitudinal and domain specific effect of prenatal fluoride exposure on IQ among children ages 4, 5, and 6-12 years in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort.
methodsWe measured the average of maternal urinary fluoride at each trimester of pregnancy adjusted for creatinine (MUF
resultsThe mean/median MUF
conclusionThe negative association between prenatal fluoride exposure and longitudinal IQ was driven by decrements in non-verbal intelligence (i.e. PIQ), suggesting that visual-spatial and perceptual reasoning abilities may be more impacted by prenatal fluoride exposure as compared to verbal abilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.