Evidence map›Paper›PMID 35276132›Full record

ArticleBiophysical journal2022

High turnover and rescue effect of XRCC1 in response to heavy charged particle radiation.

Wenjing Liu, Ruqun Wu, Jinlong Guo, Cheng Shen, Jing Zhao, Guangbo Mao, Hongjin Mou, Lei Zhang, Guanghua Du

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wenjing LiuMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; Institute of Modern Physics, University of Chinese Academy of Sciences, Beijing, China.
Ruqun WuMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China.
Jinlong GuoMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; Institute of Modern Physics, University of Chinese Academy of Sciences, Beijing, China.
Cheng ShenMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; Institute of Modern Physics, University of Chinese Academy of Sciences, Beijing, China.
Jing ZhaoMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; Institute of Modern Physics, University of Chinese Academy of Sciences, Beijing, China.
Guangbo MaoMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; School of Materials and Energy, Lanzhou University, Lanzhou, Gansu Province, China.
Hongjin MouMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; School of Materials and Energy, Lanzhou University, Lanzhou, Gansu Province, China.
Lei ZhangMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; Institute of Modern Physics, University of Chinese Academy of Sciences, Beijing, China.
Guanghua DuMaterials Research Center, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, Gansu Province, China; Institute of Modern Physics, University of Chinese Academy of Sciences, Beijing, China. Electronic address: gh_du@impcas.ac.cn.
Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The DNA damage response is a highly orchestrated process. The involvement of the DNA damage response factors in DNA damage response depends on their biochemical reactions with each other and with chromatin. Using online live-cell imaging combined with heavy ion microbeam irradiation, we studied the response of the scaffold protein X-ray repair cross-complementary protein 1 (XRCC1) at the localized DNA damage in charged particle irradiated HT1080 cells expressing XRCC1-tagged RFP. The results showed that XRCC1 was recruited to the DNA damage with ultrafast kinetics in a poly ADP-ribose polymerase-dependent manner. The consecutive reaction model well explained the response of XRCC1 at ion hits, and we found that the XRCC1 recruitment was faster and dissociation was slower in the G2 phase than those in the G1 phase. The fractionated irradiation of the same cells resulted in accelerated dissociation at the previous damage sites, and the dissociated XRCC1 immediately recycled with a higher recruitment efficiency. Our data revealed XRCC1's new rescue mechanism and its high turnover in DNA damage response, which benefits our understanding of the biochemical mechanism in DNA damage response.

Indexed as

DNA-Binding ProteinsDNA RepairDNA DamagePoly(ADP-ribose) PolymerasesX-ray Repair Cross Complementing Protein 1X-RaysDNA-Binding ProteinsPoly(ADP-ribose) PolymerasesX-ray Repair Cross Complementing Protein 1

Identifiers

PMID35276132
PMCPMC9072578
OpenAlexW4221045968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.