Evidence map›Paper›PMID 35275968›Full record

ArticlePloS one2022

Graves' disease diagnosed in remnant thyroid after lobectomy for thyroid cancer.

Meihua Jin, Ahreum Jang, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Meihua JinDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.ORCID 0000-0003-0196-631X
Ahreum JangDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
Won Gu KimDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
Tae Yong KimDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
Won Bae KimDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
Young Kee ShongDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
Min Ji JeonDivsion of endocrinology and metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
Ulsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coexistence of Graves' disease with thyroid cancer is well-known and total thyroidectomy is recommended in such cases. However, Graves' disease might be dormant at the time of surgery and diagnosed after lobectomy for thyroid cancer.

methodsWe assessed the incidence and clinicopathological characteristic of newly developed Graves' disease after lobectomy for thyroid cancer between 2010 and 2019.

resultsIn all, 11043 patients underwent lobectomy for thyroid cancer during the study period, and 26 (0.2%) were diagnosed with Graves' disease during follow-up. The median age was 43.8 years, 88.5% were female, and all were euthyroid before surgery. The median time from lobectomy to the diagnosis of Graves' disease was 3.3 years. Half of the patients were diagnosed based on thyroid function tests during routine follow-up, and others were diagnosed due to symptoms of thyrotoxicosis. Among patients who had checked preoperative thyroid autoantibodies, 61.1% showed positivity. Twenty-one (80.8%), and 2 (7.7%) patients received antithyroid drugs and radioactive iodine therapy, respectively, and 3 (11.5%) underwent completion thyroidectomy.

conclusionAlthough rare, Graves' disease can occur in the remnant thyroid after lobectomy. Such patients are more likely to have autoantibodies. An appropriate workup is required when hyperthyroidism is found during the follow-up of patients after lobectomy.

Indexed as

Graves DiseaseThyroid NeoplasmsAdultAutoantibodiesFemaleHumansIodine RadioisotopesMaleThyroidectomyAutoantibodiesIodine Radioisotopes

Identifiers

PMID35275968
PMCPMC8916678
OpenAlexW4220703363

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.