Evidence map›Paper›PMID 35275794›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution.

Iain G Johnston, Kamaludin Dingle, Sam F Greenbury, Chico Q Camargo, Jonathan P K Doye, Sebastian E Ahnert, Ard A Louis

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Exploring the protein universe with distant similarity detection methods.Protein science : a publication of the Protein Society · 2026
    Review
  6. Generative epigenetic landscapes map the topology and topography of cell fates.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Subword symmetry in natural languages.Royal Society open science · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Exploring Simplicity Bias in 1D Dynamical Systems.Entropy (Basel, Switzerland) · 2024
    Article
  19. Article
  20. Impaired face symmetry detection under alcohol, but no 'beer goggles' effect.Journal of psychopharmacology (Oxford, England) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Iain G JohnstonDepartment of Mathematics, University of Bergen, Bergen 5007, Norway.ORCID 0000-0001-8559-3519
Kamaludin DingleCentre for Applied Mathematics and Bioinformatics, Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, Hallwaly, Kuwait.
Sam F GreenburyTheory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, United Kingdom.ORCID 0000-0003-4452-2006
Chico Q CamargoDepartment of Computer Science, University of Exeter, Exeter EX4 4QF, United Kingdom.ORCID 0000-0002-2947-765X
Jonathan P K DoyePhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, United Kingdom.ORCID 0000-0002-2226-9524
Sebastian E AhnertThe Alan Turing Institute, British Library, London NW1 2DB, United Kingdom.ORCID 0000-0003-2613-0041
Ard A LouisRudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3PU, United Kingdom.ORCID 0000-0002-8438-910X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SignificanceWhy does evolution favor symmetric structures when they only represent a minute subset of all possible forms? Just as monkeys randomly typing into a computer language will preferentially produce outputs that can be generated by shorter algorithms, so the coding theorem from algorithmic information theory predicts that random mutations, when decoded by the process of development, preferentially produce phenotypes with shorter algorithmic descriptions. Since symmetric structures need less information to encode, they are much more likely to appear as potential variation. Combined with an arrival-of-the-frequent mechanism, this algorithmic bias predicts a much higher prevalence of low-complexity (high-symmetry) phenotypes than follows from natural selection alone and also explains patterns observed in protein complexes, RNA secondary structures, and a gene regulatory network.

Indexed as

Biological EvolutionInformation TheorySelection, GeneticAlgorithmsGene Regulatory NetworksPhenotypealgorithmic information theorydevelopmentevolution

Identifiers

PMID35275794
PMCPMC8931234

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.