Evidence map›Paper›PMID 35275761›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2022

D-dimer in Marfan syndrome: effect of obstructive sleep apnea induced blood pressure surges.

Mudiaga Sowho, Hartmut Schneider, Jonathan Jun, Gretchen MacCarrick, Alan Schwartz, Luu Pham, Francis Sgambati, Joao Lima, Philip Smith, Vsevolod Polotsky and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mudiaga SowhoDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3946-0605
Hartmut SchneiderAmerican Sleep Clinic, Center for Sleep Medicine, Frankfurt, Germany.
Jonathan JunDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Gretchen MacCarrickMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Alan SchwartzDepartment of Otolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Luu PhamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Francis SgambatiCenter for Interdisciplinary Sleep Research and Education, Johns Hopkins School of Medicine, Baltimore, Maryland.
Joao LimaDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Philip SmithDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Vsevolod PolotskyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Enid NeptuneDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USUniversity of Pennsylvania · US

Funding

Multi-Institutional Training in Genetic/Genomic Approaches to Sleep DisordersT32HL110952 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHERVIN, RONALD D, MIGNOT, EMMANUEL J · 2013 to 2022
$5.0M
NHLBI NIH HHS T32 HL110952
6 · The paper itself

Abstract

Aortic dissection and rupture are the major causes of premature death in persons with Marfan syndrome (MFS), a rare genetic disorder featuring cardiovascular, skeletal, and ocular impairments. We and others have found that obstructive sleep apnea (OSA) confers significant vascular stress in this population and may accelerate aortic disease progression. We hypothesized that D-dimer, a diagnostic biomarker for several types of vascular injury that is also elevated in persons with MFS with aortic enlargement, may be sensitive to cardiovascular stresses caused by OSA. To test this concept, we recruited 16 persons with MFS without aortic dissection and randomized them to two nights of polysomnography, without (baseline) and with OSA treatment: continuous positive airway pressure (CPAP). In addition to scoring OSA by the apnea-hypopnea index (AHI), beat-by-beat systolic BP (SBP) and pulse-pressure (PP) fluctuations were quantified. Morning blood samples were also assayed for D-dimer levels. In this cohort (male:female, 10:6; age, 36 ± 13 yr; aortic diameter, 4 ± 1 cm), CPAP eliminated OSA (AHI: 20 ± 17 vs. 3 ± 2 events/h,

Indexed as

Marfan SyndromeSleep Apnea, ObstructiveAdultBlood PressureContinuous Positive Airway PressureFemaleFibrin Fibrinogen Degradation ProductsHumansMaleMiddle AgedYoung AdultFibrin Fibrinogen Degradation Productsfibrin fragment DD-dimerMarfan syndromepulse pressuresleep apnea

Identifiers

PMID35275761
PMCPMC8977140
OpenAlexW4221006811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.