Evidence map›Paper›PMID 35275720›Full record

ArticleScience advances2022

GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate.

Mengyi Song, Xuefei Yuan, Claudia Racioppi, Meaghan Leslie, Nathan Stutt, Anastasiia Aleksandrova, Lionel Christiaen, Michael D Wilson, Ian C Scott

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  7. Zebrafish in Cardiovascular Disease Research: from Model to Application.International journal of biological sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Mengyi SongProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-6112-8521
Xuefei YuanProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0001-5193-9964
Claudia RacioppiCenter for Developmental Genetics, Department of Biology, New York University, New York, NY, USA.ORCID 0000-0001-8117-1124
Meaghan LeslieProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-0977-8268
Nathan StuttProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.
Anastasiia AleksandrovaProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.
Lionel ChristiaenCenter for Developmental Genetics, Department of Biology, New York University, New York, NY, USA.ORCID 0000-0001-5930-5667
Michael D WilsonProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-4015-3066
Ian C ScottProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0001-6665-1410
University of Toronto · CAHospital for Sick Children · CAHaukeland University Hospital · NONew York University · US

Funding

Regulation of muscle fate specification and cell migration in cardiogenic lineageR01HL108643 · NHLBI · NEW YORK UNIVERSITY · PI MOGILNER, ALEXANDER · 2011 to 2023
$5.4M
Modeling Gene Regulatory Networks for Early Cardiopharyngeal DevelopmentR01HD096770 · NICHD · NEW YORK UNIVERSITY · PI BONNEAU, RICHARD A, CHRISTIAEN, LIONEL · 2018 to 2022
$3.0M
NHLBI NIH HHS R01 HL108643NICHD NIH HHS R01 HD096770
6 · The paper itself

Abstract

GATA4/5/6 transcription factors play essential, conserved roles in heart development. To understand how GATA4/5/6 modulates the mesoderm-to-cardiac fate transition, we labeled, isolated, and performed single-cell gene expression analysis on cells that express

Indexed as

GATA4 Transcription FactorZebrafishAnimalsGATA5 Transcription FactorGene Expression Regulation, DevelopmentalMesodermGATA4 Transcription FactorGATA5 Transcription Factor

Identifiers

PMID35275720
PMCPMC8916722
OpenAlexW4220952537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.