Evidence map›Paper›PMID 35275301›Full record

ArticleDoklady. Biochemistry and biophysics2022

Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators.

O V Kyrchanova, N Y Postika, V V Sokolov, P G Georgiev

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

O V KyrchanovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. olna73@gmail.com.
N Y PostikaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
V V SokolovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
P G GeorgievInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Institute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The segment-specific regulatory domains of the Bithorax complex (BX-C), which consists of three homeotic genes Ubx, abd-A and Abd-B, are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for higher eukaryotes. As was shown previously, the CTCF sites determine the insulator activity of the boundaries of the Abd-B regulatory region. In this study, it was shown that fragments of the Fab-3 and Fab-4 boundaries of the abd-A regulatory region, containing CTCF binding sites, are not effective insulators.

Indexed as

CCCTC-Binding FactorDrosophila melanogasterDrosophila ProteinsAnimalsBinding SitesGenes, HomeoboxHomeodomain ProteinsInsulator ElementsTranscription FactorsCCCTC-Binding FactorCTCF protein, DrosophilaDrosophila ProteinsHomeodomain ProteinsTranscription FactorsUbx protein, Drosophilaabd-AAbd-Barchitectural proteinsdCTCFFab-7insulatorsregulatory domain

Identifiers

PMID35275301
PMCPMC8917101
OpenAlexW4220679222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.