Evidence map›Paper›PMID 35274819›Full record

ArticlePhysiological reports2022

The answer at our fingertips: Volume status in cirrhosis determined by machine learning and pulse oximeter waveform.

Nikhilesh R Mazumder, Avidor Kazen, Andrew Carek, Mozziyar Etemadi, Josh Levitsky

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nikhilesh R MazumderDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-9749-5334
Avidor KazenCardiosense Inc, Chicago, Illinois, USA.
Andrew CarekCardiosense Inc, Chicago, Illinois, USA.
Mozziyar EtemadiMcCormick School of Engineering, Northwestern University, Chicago, Illinois, USA.
Josh LevitskyDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-7527-6093
Northwestern University · USSociety of Gastroenterology Nurses and Associates · USUniversity of Michigan · US

Funding

Transplant Surgery Scientist Training ProgramT32DK077662 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Richard M Green, Daniela P Ladner · 2007 to 2026
$3.8M
NIDDK NIH HHS T32 DK077662
6 · The paper itself

Abstract

objectiveThe objective of our study was to determine if the waveform from a simple pulse oximeter-like device could be used to accurately assess intravascular volume status in cirrhosis.

methodsPatients with cirrhosis underwent waveform recording as well as serum brain natriuretic peptide (BNP) on the day of their cardiac catheterization where invasive cardiac pressures were measured. Waveforms were processed to generate features for machine learning models in order to predict the filling pressures (regression) or to classify the patients as volume overloaded or not (defined as an LVEDP>15).

resultsNine of 26 patients (35%) had intravascular volume overload. Regression analysis using PPG features (R

conclusionsMachine learning-enhanced analysis of pulse ox waveforms can estimate intravascular volume overload with a higher accuracy than conventionally measured BNP.

Indexed as

Natriuretic Peptide, BrainOximetryHumansLiver CirrhosisMachine LearningOxygenNatriuretic Peptide, BrainOxygenbiomarkerscirrhosismachine learningphysiology

Identifiers

PMID35274819
PMCPMC8915710
OpenAlexW4221055949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.