Evidence map›Paper›PMID 35274816›Full record

ArticlePhysiological reports2022

miRNAs as markers for the development of individualized training regimens: A pilot study.

Manuel Widmann, Felipe Mattioni Maturana, Christof Burgstahler, Gunnar Erz, Philipp Schellhorn, Annunziata Fragasso, Angelika Schmitt, Andreas M Nieß, Barbara Munz

Abstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-coding RNAs in exercise immunology: A systematic review.Journal of sport and health science · 2024
    Pooled it
  2. Trial
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manuel WidmannDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Felipe Mattioni MaturanaDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0002-4221-6104
Christof BurgstahlerDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Gunnar ErzDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Philipp SchellhornDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Annunziata FragassoDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Angelika SchmittDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Andreas M NießDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.
Barbara MunzDepartment of Sports Medicine, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0002-4582-6119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small, non-coding RNAs (microRNAs) have been shown to regulate gene expression in response to exercise in various tissues and organs, thus possibly coordinating their adaptive response. Thus, it is likely that differential microRNA expression might be one of the factors that are responsible for different training responses of different individuals. Consequently, determining microRNA patterns might be a promising approach toward the development of individualized training strategies. However, little is known on (1) microRNA patterns and their regulation by different exercise regimens and (2) possible correlations between these patterns and individual training adaptation. Here, we present microarray data on skeletal muscle microRNA patterns in six young, female subjects before and after six weeks of either moderate-intensity continuous or high-intensity interval training on a bicycle ergometer. Our data show that n = 36 different microRNA species were regulated more than twofold in this cohort (n = 28 upregulated and n = 8 downregulated). In addition, we correlated baseline microRNA patterns with individual changes in VO

Indexed as

MicroRNAsAdaptation, PhysiologicalBiomarkersExerciseFemaleHumansMuscle, SkeletalPilot ProjectsBiomarkersMicroRNAsindividual training adaptationmicroRNAsphysical exerciseskeletal muscle

Identifiers

PMID35274816
PMCPMC8915711

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.