Evidence map›Paper›PMID 35274490›Full record

ArticleESC heart failure2022

Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19.

Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C Schefold, Detlef Kindgen-Milles, Philipp Heinrich Baldia, Malte Kelm and 19 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04321265 (Outcomes and Prognostic Factors in Coronavirus Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04321265 unknown statusnot on this map

Outcomes and Prognostic Factors in Coronavirus Disease (COVID-19) in Very Old Intensive Care Patients

TypeobservationalSponsorHeinrich-Heine University, DuesseldorfRan2020 to 2023Enrolled1,500ConditionsCOVID-19, Elderly Patients, Critical Illness, Survival
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 18 countries.

Raphael Romano BrunoDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0003-3776-3530
Bernhard WernlyCenter for Public Health and Healthcare Research, Paracelsus Medical University Salzburg, Salzburg, Austria.
Georg WolffDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Jesper FjølnerDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Antonio ArtigasDepartment of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain.
Bernardo Bollen PintoDepartment of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland.
Joerg C SchefoldDepartment of Intensive Care Medicine, Inselspital, Universitätsspital Bern, University of Bern, Bern, Switzerland.
Detlef Kindgen-MillesDepartment of Anesthesiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Philipp Heinrich BaldiaDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Michael BeilDepartment of Medical Intensive Care, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Sigal SviriDepartment of Medical Intensive Care, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Peter Vernon van HeerdenGeneral Intensive Care Unit, Department of Anaesthesiology, Critical Care and Pain Medicine, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Wojciech SzczeklikCenter for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland.
Arzu TopeliDivision of Intensive Care, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Sandra OeyenDepartment of Intensive Care 1K12IC, Ghent University Hospital, Ghent, Belgium.
Eumorfia KondiliIntensive Care Unit, Department of Intensive Care Medicine, University Hospital of Heraklion, Heraklion, Greece.
Brian MarshMater Misericordiae University Hospital, Dublin, Ireland.
Finn H AndersenDepartment of Anaesthesia and Intensive Care, Ålesund Hospital, Ålesund, Norway.
Rui MorenoUnidade de Cuidados Intensivos Neurocríticos e Trauma, Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de Lisboa, Nova Medical School, Lisbon, Portugal.
Susannah LeaverGeneral Intensive Care, St George's University Hospitals NHS Foundation Trust, London, UK.
Ariane BoumendilSorbonne Universités, UPMC Univ Paris 06, INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe: épidémiologie hospitalière qualité et organisation des soins, Paris, France.
Dylan W De LangeDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bertrand GuidetSorbonne Universités, UPMC Univ Paris 06, INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe: épidémiologie hospitalière qualité et organisation des soins, Paris, France.
Hans FlaattenDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Christian JungDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-8325-250X
COVIP study group
Heinrich Heine University Düsseldorf · DEHebrew University of Jerusalem · ILInserm · FRAarhus University Hospital · DKGhent University Hospital · BEHacettepe University · TRHaukeland University Hospital · NOHospital de São José · PTInnsbruck Medical University · ATJagiellonian University · PLMater Misericordiae University Hospital · IENorwegian University of Science and Technology · NOParacelsus Medical University · ATSt George’s University Hospitals NHS Foundation Trust · GBUniversitat Autònoma de Barcelona · ESUniversity Hospital of Geneva · CHUniversity Hospital of Heraklion · GRUniversity of Bern · CHUniversity of Tripoli · LYUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsChronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. METHODS AND

resultsPatients with pre-existing CHF were subclassified as having ischaemic or non-ischaemic cardiac disease; patients with a documented ejection fraction (EF) were subclassified according to heart failure EF: reduced (HFrEF, n = 132), mild (HFmrEF, n = 91), or preserved (HFpEF, n = 103). Associations of heart failure characteristics with the 30 day mortality were analysed in univariate and multivariate logistic regression analyses. Pre-existing CHF was reported in 566 of 3917 patients (14%). Patients with CHF were older, frailer, and had significantly higher SOFA scores on admission. CHF patients showed significantly higher crude 30 day mortality [60% vs. 48%, P < 0.001; odds ratio 1.87, 95% confidence interval (CI) 1.5-2.3] and 3 month mortality (69% vs. 56%, P < 0.001). After multivariate adjustment for confounders (SOFA, age, sex, and frailty), no independent association of CHF with mortality remained [adjusted odds ratio (aOR) 1.2, 95% CI 0.5-1.5; P = 0.137]. More patients suffered from pre-existing ischaemic than from non-ischaemic disease [233 vs. 328 patients (n = 5 unknown aetiology)]. There were no differences in baseline characteristics between ischaemic and non-ischaemic disease or between HFrEF, HFmrEF, and HFpEF. Crude 30 day mortality was significantly higher in HFrEF compared with HFpEF (64% vs. 48%, P = 0.042). EF as a continuous variable was not independently associated with 30 day mortality (aOR 0.98, 95% CI 0.9-1.0; P = 0.128).

conclusionsIn critically ill older COVID-19 patients, pre-existing CHF was not independently associated with 30 day mortality. TRIAL REGISTRATION NUMBER: NCT04321265.

Indexed as

COVID-19Heart FailureChronic DiseaseCritical CareCritical IllnessHospitalizationHumansPrognosisProspective StudiesStroke VolumeCOVID-19ElderlyHeart failure

Identifiers

PMID35274490
PMCPMC9065875
OpenAlexW4221074295

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.