ArticleCancer medicine2022
Characteristics of anal canal cancer in Japan.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Stage-dependent differences of long-term outcomes between chemoradiotherapy and surgery for squamous cell carcinoma of the anal canal: a multicenter retrospective cohort study.International journal of clinical oncology · 2026Article
- Cancer epidemiology in rare and hereditary colorectal diseases 2) anal canal cancer (cancer statistics).International journal of clinical oncology · 2026Review
- Risk Factors for Colostomy after Chemoradiotherapy in Patients with Squamous Cell Carcinoma of the Anus: A Nationwide, Multicenter Analysis in Japan.Journal of the anus, rectum and colon · 2026Article
- Article
- Metastatic Status and Dissection Effect of Regional/Extraregional Lymph Nodes in Japanese Patients with Squamous Cell Carcinoma of the Anal Canal: A Multicenter Retrospective Cohort Study.Journal of the anus, rectum and colon · 2025Article
- Clinicopathological Features by Differentiation and Prognostic Factors in Anal Canal Carcinoma.Journal of the anus, rectum and colon · 2025Article
- The inguinal lymph nodes as regional lymph nodes in anal canal adenocarcinomas: a nationwide database analysis in Japan.Surgery today · 2024Article
- Clinical outcomes and prognostic factors of concurrent chemoradiotherapy for anal squamous cell carcinoma in Japan.International journal of clinical oncology · 2024Article
- Local excision versus radical surgery for anal squamous cell carcinoma: a multicenter study in Japan.International journal of clinical oncology · 2024Article
- Significance of lateral lymph node dissection in squamous cell carcinoma of the anal canal: a retrospective cohort study.Langenbeck's archives of surgery · 2024Article
- Squamous cell carcinoma of the anus successfully treated with multidisciplinary therapy for metachronous metastatic and local recurrences after DCF chemotherapy: a case report.Surgical case reports · 2024Article
- A Population-Based and Propensity Score-Matched Investigation of the Occurrence, Management, and Prognosis of Anal Mucinous Adenocarcinoma Patients.Oncology research and treatment · 2024Article
- Clinicopathologic Factors Associated with Prognosis in Patients with Metastatic Squamous Cell Carcinoma of the Anal Canal: A Multicenter Cohort Study.Journal of the anus, rectum and colon · 2024Article
- Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.International journal of clinical oncology · 2023Review
- Characteristics of anal canal cancer in Japan.Cancer medicine · 2022Article
- Stage IV anal canal squamous cell carcinoma with long-term survival: a case report.Surgical case reports · 2022Article
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48 authors.
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Abstract
Anal canal cancer (ACC) has been reported to be an uncommon cancer in Japan, as in the USA, Europe, and Australia. This retrospective multi-institutional study was conducted to clarify the characteristics of ACC in Japan. First, the histological ACC type cases treated between 1991 and 2015 were collected. A detailed analysis of the characteristics of anal canal squamous cell carcinoma (SCC) cases was then conducted. The results of the histological types revealed that of the 1781 ACC cases, 435 cases (24.4%) including seven cases of adenosquamous cell carcinomas were SCC and 1260 cases (70.7%) were adenocarcinoma. However, the most common histological type reported in the USA, Europe, and Australia is SCC. Most ACC cases are adenocarcinomas and there is a low incidence of SCC in Japan which is different from the above-mentioned countries. Moreover, we reclassified T4 into the following two groups based on tumor size: T4a (tumor diameter of 5 cm or less) and T4b (tumor diameter of more than 5 cm). The results of the TNM classification of SCC revealed that the hazard ratio (HR) to T1 of T2, T3, T4a, and T4b was 2.45, 2.28, 2.89, and 4.97, respectively. As T4b cases had a worse prognosis than T4a cases, we propose that T4 for anal canal SCC in Japan be subclassified into T4a and T4b.
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