ArticleMovement disorders : official journal of the Movement Disorder Society2022
Gastrointestinal Symptoms and Dopamine Transporter Asymmetry in Early Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Age at onset of Parkinson's disease modulates the sphingolipid-dopaminergic interplay in autonomic progression.NPJ Parkinson's disease · 2026Article
- Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson's disease.npj women's health · 2026Article
- Peripheral inflammatory markers and clinical phenotypes reflecting the impact of diabetes on Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Discriminating between proposed Brain-First and Body-First Parkinson's disease using conventional and radiomics-enhanced dopamine transporter SPECT image analysis.NPJ Parkinson's disease · 2025Article
- Increased frontal [NPJ Parkinson's disease · 2025Article
- Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus.Movement disorders clinical practice · 2025Article
- Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease.Brain and behavior · 2023Article
- The complex role of inflammation and gliotransmitters in Parkinson's disease.Neurobiology of disease · 2023Review
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Authors and funding
15 authors.
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Abstract
backgroundThe neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal origin of PD dopaminergic neurodegeneration would be more symmetric.
objectivesThe aim is to assess the associations between GISs and asymmetry of nigrostriatal dopaminergic neurodegeneration in PD.
methodsNinety PD patients were assessed using motor and GIS scales and
resultsThere were no significant differences in GISs between symmetric and asymmetric dopaminergic defect. Left predominant defect was related to more GIS and higher constipation scores.
conclusionsGISs were associated with left predominant reduction in putaminal DAT binding but not asymmetry per se. It remains open whether left-sided DAT deficit is related to more pronounced GI involvement or symptom perception in PD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.
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