Evidence map›Paper›PMID 35274335›Full record

ArticleStatistics in medicine2022

A semi-parametric Bayesian model for semi-continuous longitudinal data.

Junting Ren, Susan Tapert, Chun Chieh Fan, Wesley K Thompson

Open access · greenAbstract read
In one paragraph

Article in Statistics in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Initial Subjective Response to Nicotine Vaping Predicts Subsequent E-Cigarette Use in Early Adolescence: An ABCD Investigation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  5. Article
  6. Longitudinal analysis of the ABCD® study.Developmental cognitive neuroscience · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Junting RenDivision of Biostatistics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-7492-6864
Susan TapertDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Chun Chieh FanPopulation Neuroscience and Genetics Lab, University of California San Diego, La Jolla, California, USA.
Wesley K ThompsonPopulation Neuroscience and Genetics Lab, University of California San Diego, La Jolla, California, USA.
University of California San Diego · US

Funding

NCANDA: Data Analysis Resource - Uploading Legacy Data to NDAU24AA021697 · NIAAA · STANFORD UNIVERSITY · PI Adolf Pfefferbaum, Kilian Maria Pohl · 2016 to 2026
$12.2M
National Consortium on Alcohol and NeuroDevelopment in Adolescence: San DiegoU01AA021692 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Susan F. Tapert · 2012 to 2026
$11.8M
National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative ResourceU24AA021695 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, Susan F. Tapert · 2016 to 2026
$6.0M
Identifying and quantifying genetic effects on neurodevelopmental trajectories in adolescentsR01MH122688 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAN, CHUN CHIEH · 2020 to 2024
$1.8M
Data Exploration and Analysis Portal for Brain Research through Advanced Imaging NeuroscienceRF1MH120025 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAN, CHUN CHIEH, THOMPSON, WESLEY KURT · 2020 to 2020
$1.1M
NIAAA NIH HHS U01 AA021692NIAAA NIH HHS U24 AA021695NIAAA NIH HHS U24 AA021697NIH HHS 5U24AA021695-09NIH HHS 5U24AA021697-09NIH HHS MH120025NIH HHS MH122688NIMH NIH HHS R01 MH122688NIMH NIH HHS RF1 MH120025
6 · The paper itself

Abstract

Semi-continuous data present challenges in both model fitting and interpretation. Parametric distributions may be inappropriate for extreme long right tails of the data. Mean effects of covariates, susceptible to extreme values, may fail to capture relevant information for most of the sample. We propose a two-component semi-parametric Bayesian mixture model, with the discrete component captured by a probability mass (typically at zero) and the continuous component of the density modeled by a mixture of B-spline densities that can be flexibly fit to any data distribution. The model includes random effects of subjects to allow for application to longitudinal data. We specify prior distributions on parameters and perform model inference using a Markov chain Monte Carlo (MCMC) Gibbs-sampling algorithm programmed in R. Statistical inference can be made for multiple quantiles of the covariate effects simultaneously providing a comprehensive view. Various MCMC sampling techniques are used to facilitate convergence. We demonstrate the performance and the interpretability of the model via simulations and analyses on the National Consortium on Alcohol and Neurodevelopment in Adolescence study (NCANDA) data on alcohol binge drinking.

Indexed as

AlgorithmsModels, StatisticalBayes TheoremHumansMarkov ChainsMonte Carlo MethodBayesianB-splinelongitudinalMarkov chain Monte Carlosemi-continuoussemi-parametric

Identifiers

PMID35274335
PMCPMC9035098
OpenAlexW4220684316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.