ArticleJournal of molecular neuroscience : MN2022
Crocin Protects Malathion-Induced Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats' Striatum.
Article in Journal of molecular neuroscience : MN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05696665 (Role of Saffron and Chamomile and Their Active Compounds in the Management of Parkinson Disease in the Context of Psychometric and Biochemical Measures), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Saffron and Chamomile and Their Active Compounds in the Management of Parkinson Disease in the Context of Psychometric and Biochemical Measures
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pesticide exposure and the development of Parkinson disease: a systematic review of Brazilian studies.Cadernos de saude publica · 2025Pooled it
- Rosemary (Iranian journal of basic medical sciences · 2026Review
- A Review of Antioxidant Activity, Anti-Inflammatory Properties, Apoptosis-Regulatory Effects, and Immune System Modulation ofFood science & nutrition · 2025Review
- Crocin Improves Cognitive Impairment in LPS-treated Rats through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities.Molecular neurobiology · 2025Article
- Protective effect of aspirin and gentisic acid, a plant-derived phenolic acid, on acrylamide-induced neurotoxicity by inhibiting apoptosis and autophagy.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Herbal medicine approach to relieving dyspnea: A narrative review of efficacy and mechanisms.Iranian journal of basic medical sciences · 2025Review
- Assessing the efficacy of herbal supplements for managing obesity: A comprehensive review of global clinical trials.Iranian journal of basic medical sciences · 2025Review
- Trans-sodium crocetinate ameliorates Parkinson-like disease caused by bisphenol A through inhibition of apoptosis and reduction of α-synuclein in rats.Iranian journal of basic medical sciences · 2025Article
- Effect ofIranian journal of basic medical sciences · 2025Review
- The power of trans-sodium crocetinate: exploring its renoprotective effects in a rat model of colistin-induced nephrotoxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations.Iranian journal of basic medical sciences · 2024Article
- Neuroprotective effects of walnutIranian journal of basic medical sciences · 2024Review
- Renoprotective effects of crocin against colistin-induced nephrotoxicity in a rat model.Iranian journal of basic medical sciences · 2024Article
- The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides.Archives of toxicology · 2023Review
- The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review.Brain sciences · 2023Review
- Ameliorative effects ofIranian journal of basic medical sciences · 2023Review
- Crocin mitigates colistin-induced toxicity in HEK-293 cells through antioxidant and antiapoptotic mechanisms.Avicenna journal of phytomedicineArticle
- Evaluating the effect of crocin on contrast-induced nephropathy in rats.Avicenna journal of phytomedicineArticle
- Antioxidant, anti-inflammatory and cytoprotective effects of crocin, a bioactive constituent of saffron, in Alzheimer's and Parkinson's diseases with a focus on molecular mechanisms: A systematic review.Avicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Long-term exposure to organophosphates might result in neurodegenerative diseases, comprising Parkinson's disease. Malathion is an organophosphate pesticide with high neurotoxicity. Oxidative stress, apoptosis, and α-synuclein accumulation are important underlying mechanisms in Parkinson's disease. According to studies, crocin, an active constituent of saffron, has anti-apoptotic, anti-inflammatory, and antioxidant properties. Thus, the effect of crocin on malathion-induced striatal biochemical deficits in rats was investigated in this study. Six groups of male Wistar rats were used: 1. control (normal saline); 2. malathion (100 mg/kg/day, i.p.); 3. crocin (10 mg/kg/day, i.p.) + malathion; 4. levodopa (10 mg/kg/day, i.p.) + malathion; 5. crocin (40 mg/kg/day, i.p.); and 6. polyethylene glycol (PEG) (vehicle of levodopa) groups. The drugs were administered for 28 days. The amounts of Bcl-2, Bax, and caspases 3, 8, and 9 proteins in the striatum were measured by western blotting. Also, the amounts of protein and mRNA level of the α-synuclein in striatum tissue were measured by western blotting and RT-qPCR methods. Malathion induced apoptosis by increasing the amount of Bax/Bcl2 ratio and caspases 3 and 9 proteins in rat striatum tissue. It also increased the protein and mRNA level of α-synuclein in striatal tissue. Co-administration of crocin or levodopa with malathion inhibited the toxic effects of malathion on striatal tissue. Crocin ameliorates the neurotoxic effect of malathion by its anti-apoptotic activity and regulating the expression of proteins involved in Parkinson's disease pathogenesis. As a result, crocin has the potential to be used as a treatment for malathion-induced neurotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.